Mushrooms for Nerve Health-Our Research Findings

机译：促进神经健康的蘑菇-我们的研究发现

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Culinary and medicinal mushrooms are renowned for their health benefits on the various systems in the human body that can contribute to wellness and quality of life. As we age, we are prone to a number of life debilitating diseases including nerve related diseases. Further, dementia and Alzheimer's diseases are the most devastating. In traditional Chinese and Japanese therapy, Hericium erinaceus has been reported to help stimulate neurite outgrowth which may help reduce or delay on set of dementia. In this study, other culinary and medicinal mushrooms including the edible Pleurotus giganteus and nonedible Lignosus rhinocerus and Ganoderma neojaponicum were investigated for benefits to the nervous system. The extracts of fruiting bodies, sclerotia or mycelium of the selected mushrooms stimulated neurite outgrowth of PC 12 cells. All three mushrooms had varying degrees of stimulatory activities on neurite outgrowth. The activities of L. Rhinocerus, a wild medicinal mushroom were comparable or significantly better at low concentrations when compared to aqueous and ethanol extracts of H. Erinaceus extracts and nerve growth factor (NGF). Aqueous extract of all three mushrooms studied contained bioactive molecules that mimic NGF that is responsible for neurite stimulation activity. The extracts were not toxic to cell lines used in this study. Further, the extracts had genoprotective and anti-inflammatory activities that may contribute to nerve health, too.

机译：烹饪和药用蘑菇以其对人体各种系统的健康益处而闻名，这些系统可以促进健康和生活质量。随着年龄的增长，我们容易患上许多破坏生命的疾病，包括神经相关疾病。此外，痴呆症和阿尔茨海默氏病是最具破坏性的。在传统的中国和日本疗法中，已报道猴头猴有助于刺激神经突向外生长，这可能有助于减少或延缓痴呆。在这项研究中，研究了其他食用菌和药用蘑菇，包括食用平菇，不可食用的犀牛和新灵芝，它们对神经系统有好处。选定蘑菇的子实体，菌核或菌丝体的提取物刺激了PC 12细胞的神经突生长。这三种蘑菇对神经突的生长都有不同程度的刺激作用。与犀牛肝菌提取物和神经生长因子（NGF）的水提取物和乙醇提取物相比，野生药用蘑菇犀牛的活性在低浓度下具有可比性或明显更好。研究的所有三个蘑菇的水提取物均含有模仿NGF的生物活性分子，NGF负责神经突的刺激活性。提取物对本研究中使用的细胞系无毒。此外，提取物还具有基因保护和抗炎活性，也可能有助于神经健康。

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来源
《Proceedings of the 18th congress of the International Society for Mushroom Science》|2012年|439-447|共9页
会议地点 Beijing(CN)
作者
Vikineswary Sabaratnam; Murali Naidu; Pamela David; Wong Kah Hui; Tan Yee Shin; Sri Nurestri Abdul Malek;
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作者单位

Mushroom Research Centre Institute of Biological Sciences, Faculty of Science, University of Malaya,Kuala Lumpur 50603 , Malaysia;

Mushroom Research Centre Department of Anatomy, University of Malaya, Kuala Lumpur 50603,Malaysia;

Mushroom Research Centre Department of Anatomy, University of Malaya, Kuala Lumpur 50603,Malaysia;

Mushroom Research Centre Department of Anatomy, University of Malaya, Kuala Lumpur 50603,Malaysia;

Mushroom Research Centre Institute of Biological Sciences, Faculty of Science, University of Malaya,Kuala Lumpur 50603 , Malaysia;

Mushroom Research Centre Institute of Biological Sciences, Faculty of Science, University of Malaya,Kuala Lumpur 50603 , Malaysia;

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会议组织
原文格式 PDF
正文语种 eng
中图分类菌类（食用菌）;
关键词
Neurodegenerative Diseases; Lignosus rhinocerus; Hericium erinaceus; Pleurotus giganteus; Ganoderma neo-japonicum; Neurite Outgrowth Stimulatory Activity; Genoprotection; Nerve Regeneration; Curcumin; Gingko; MAP/ERK Signalling Pathway; PI3K Signalling Pathw;

机译：神经退行性疾病;木犀牛;猴头猴;灵芝侧耳;日本灵芝;神经元增生刺激活性;基因保护;神经再生;姜黄素;银杏; MAP / ERK信号通路; PI3K信号通路;

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1. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae) (vol 2011, 580752, 2011) [J] . Wong Kah-Hui, Naidu Murali, David Pamela, Evidence-based complementary and alternative medicine: eCAM . 2018,第14期

机译：通过药用蘑菇血腥群（公牛队：Fr）的水提取物，对大鼠腓骨神经进行粉碎后神经再生后的外周神经再生。（Aphyllophoromycetideae）（2011年第2011,580752，2011）
2. Periscapular muscle ultrasound as a diagnostic aid in scapular winging secondary to long thoracic nerve lesion. Comment on "Magnetic resonance imaging of dynamic scapular winging secondary to a lesion of the long thoracic nerve" by Nguyen et al. and on "A case of traumatic long thoracic nerve suffering: High-frequency ultrasound finding" by Coraci et al [J] . Misirlioglu Tugce Ozekli, Palamar Deniz, Akgun Kenan Joint, bone, spine : . 2019,第2期

机译：脊椎肌肉超声作为肩胛翅膀中的诊断辅助辅助辅助辅助辅助胸部长期胸神经病变。 Nguyen等人对“长胸神经动态肩胛翅膀的磁共振成像评析”。并在“创伤性长胸神经痛苦的情况下：Coraci等人的高频超声发现”
3. Benign peripheral nerve sheath tumor of digit versus major-nerve: Comparison of MRI findings [J] . Seul Ki Lee, Jee-Young Kim, Hyang Sook Jeong PLoS One . 2020,第3期

机译：良性周围神经鞘瘤与主要神经：MRI调查结果的比较
4. Mushrooms for Nerve Health-Our Research Findings [C] . Vikineswary Sabaratnam, Murali Naidu, Pamela David, Congress of the International Society for Mushroom Science . 2012

机译：神经健康的蘑菇 - 我们的研究结果
5. Genome Sequence of Shiitake Mushroom Lentinula edodes and Comparative Mushroom Genomics with Platform Construction. [D] . Au, Chun Hang. 2011

机译：香菇香菇的基因组序列和平台构建的比较香菇基因组学。
6. Corrigendum to Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae) [O] . Kah-Hui Wong, Murali Naidu, Pamela David, 2018

机译：药用蘑菇猴头菇提取物对大鼠腓神经的挤压伤后外周神经再生的更正（公牛：Fr）。（无节菌科）
7. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae) [O] . Wong, Kah-Hui, Naidu, Murali, David, Pamela, 2011

机译：药用蘑菇猴头菇提取物对大鼠腓神经的压迫性损伤后周围神经的再生（Bull .: Fr）Pers。（金光眼科）
8. Mushrooms in the Mist: Stalking the Wild Chanterelle. Science Findings, Issue Twelve, March 1999. [R] . 1999

机译：雾中的蘑菇：跟踪野生鸡油菌。科学发现，问题十二，1999年3月。

Mushrooms for Nerve Health-Our Research Findings

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