A model of tumor growth coupling a cellular biomodel with biomechanical simulations

机译：肿瘤生长模型将细胞生物模型与生物力学模拟耦合在一起

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The aim of this paper is to present the development of a multi-scale and multiphysics approach to tumor growth. An existing biomodel used for clinical tumor growth and response to treatment has been coupled with a biomechanical model. The macroscopic mechanical model is used to provide directions of least pressure in the tissue, which drives the geometrical evolution of the tumor predicted at the cellular level. The combined model has been applied to the case of brain and lung tumors. Results indicated that the coupled approach provides additional morphological information on the realistic tumor shape when the tumor is located in regions of tissue inhomogeneity. The approach might be used in oncosimulators for tumor types where the morphometry information plays a major role in the treatment and surgical planning.

机译：本文的目的是提出一种多尺度，多物理场的肿瘤生长方法。用于临床肿瘤生长和对治疗的反应的现有生物模型已经与生物力学模型结合。宏观力学模型用于提供组织中压力最小的方向，从而驱动在细胞水平上预测的肿瘤的几何演变。组合模型已应用于脑和肺部肿瘤。结果表明，当肿瘤位于组织不均匀性区域时，耦合方法可提供有关实际肿瘤形状的其他形态学信息。该方法可用于肿瘤类型的癌模拟仪中，其中形态计量信息在治疗和手术计划中起主要作用。

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来源
《Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The TUMOR Project Workshop》|2014年|1-4|共4页
会议地点 Athens(GR)
作者
Rikhtegar Farhad; Kolokotroni Eleni; Stamatakos Georgios; Buchler Philippe;
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作者单位

Inst. for Surg. Technol. Biomech., Univ. of Bern, Bern, Switzerland;

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会议组织
原文格式 PDF
正文语种 eng
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关键词
biomechanics; brain; cancer; cellular biophysics; finite element analysis; lung; tumours; biomechanical simulations; brain tumor biomechanical model; cellular biomodel; clinical tumor growth; coupled multiscale-multiphysics approach; geometrical tumor evolution; least tissue pressure; lung tumor biomechanical model; macroscopic mechanical model; morphometry information; multiphysics tumor growth approach; multiscale tumor growth approach; oncosimulators; realistic tumor shape; surgical planning; tissue inhomogeneity;

机译：生物力学;脑;癌症;细胞生物物理学;有限元分析;肺;肿瘤;生物力学模拟;脑肿瘤生物力学模型;细胞生物模型;临床肿瘤生长;多尺度-多物理场耦合方法;几何肿瘤演变;最小组织压力;肺肿瘤生物力学模型宏观力学模型形态计量学信息多物理场肿瘤生长方法多尺度肿瘤生长方法辅助仿真器真实的肿瘤形状手术计划组织不均匀性;

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专利

1. 作物生长模型同化SAR数据模拟作物生物量时域变化特征 [J] . 谭正, 刘湘南, 张晓倩, 农业科学与技术（英文版） . 2012,第005期
2. Coupling biomechanics to a cellular level model: An approach to patient-specific image driven multi-scale and multi-physics tumor simulation [J] . May Christian P., Kolokotroni Eleni, Stamatakos Georgios S., Progress in Biophysics and Molecular Biology: An International Review Journal . 2011,第1期

机译：将生物力学耦合到细胞水平模型：一种针对患者的图像驱动多尺度和多物理场肿瘤模拟的方法
3. Realistic simulation of the 3-D growth of brain tumors in MR images coupling diffusion with biomechanical deformation [J] . Clatz O., Sermesant M., Bondiau P.-Y., IEEE Transactions on Medical Imaging . 2005,第10期

机译：MR图像中扩散与生物力学变形耦合的脑肿瘤3-D生长的现实模拟
4. An optimized generic cerebral tumor growth modeling framework by coupling biomechanical and diffusive models with treatment effects [J] . Elazab Ahmed, Anter Ahmed M., Bai Hongmin, Applied Soft Computing . 2019,第期

机译：通过治疗效果耦合生物力学和扩散模型的优化通用脑肿瘤生长建模框架
5. A model of tumor growth coupling a cellular biomodel with biomechanical simulations [C] . Rikhtegar Farhad, Kolokotroni Eleni, Stamatakos Georgios, International Advanced Research Workshop on In Silico Oncology and Cancer Investigation . 2014

机译：肿瘤生长模型耦合生物力学模拟蜂窝生物偶像
6. Modeling and Simulation of Tumor Growth by Finite Element and Machine Learning Method [D] . Sun, Hao. 2021

机译：有限元和机器学习方法肿瘤生长的建模与仿真
7. Realistic Simulation of the 3D Growth of Brain Tumors in MR Images Coupling Diffusion with Biomechanical Deformation [O] . Olivier Clatz, Maxime Sermesant, Pierre-Yves Bondiau, -1

机译：MR图像与生物力学变形耦合扩散中脑肿瘤3D生长的逼真模拟
8. Realistic simulation of the 3d growth of brain tumors in mr images coupling diffusion with biomechanical deformation [O] . Olivier Clatz, Maxime Sermesant, Pierre-Yves Bondiau, 2005

机译：MR图像中扩散与生物力学变形耦合的脑肿瘤3d生长的逼真模拟

A model of tumor growth coupling a cellular biomodel with biomechanical simulations

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