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首页> 外文会议>Proceedings of the 34th IASTED International Conference on Modelling, Identification and Control >SENSITIVITY OF CONTROLLABILITY CONDITIONS FOR MODELS OF COMBINED ANTICANCER THERAPY
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SENSITIVITY OF CONTROLLABILITY CONDITIONS FOR MODELS OF COMBINED ANTICANCER THERAPY

机译：联合抗癌药物治疗模型的可控性条件敏感性

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摘要

We analyze sensitivity of sufficient conditions for local controllability for a class of models of treatment response to combined anticancer therapies. The combined therapy is understood as combination of direct anticancer strategy e.g. chemotherapy and indirect modality (in this case antiangiogenic therapy). Controllability of the models in the form of semilinear second order dynamic systems enables to expect that different objectives of treatment could be reached. We discuss the effect of different models of cancer growth (Gomperztian vs. logistic) and supporting vascular network growth. Moreover we analyze also sensitivity of controllability conditions with respect to delays in treatment actions.
机译：我们分析了针对联合抗癌疗法的一类治疗模型的局部可控性的充分条件的敏感性。组合疗法应理解为直接抗癌策略的组合，例如联合使用。化学疗法和间接疗法（在这种情况下为抗血管生成疗法）。以半线性二阶动态系统形式的模型的可控制性使人们期望可以达到不同的治疗目标。我们讨论了癌症生长不同模型（Gomperztian与Logistic）的影响，并支持了血管网络的生长。此外，我们还分析了可控性条件相对于治疗措施延迟的敏感性。

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