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首页> 外文会议>Proceedings of the 43rd annual loss prevention symposium >APPROACH FOR THE DEVELOPMENT OF A MORE EFFICIENT AND SAFER PROCESS IN THE PHARMACEUTICAL INDUSTRY
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APPROACH FOR THE DEVELOPMENT OF A MORE EFFICIENT AND SAFER PROCESS IN THE PHARMACEUTICAL INDUSTRY

机译：在制药行业中开发更高效，更安全的过程的方法

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摘要

Risks are present in chemical reactions due to the properties of the chemicals and the potentially hazardous situations that can be developed under abnormal conditions. These reactions are employed in industrial processes, but a need exists to improve technologies and find alternatives that lead to safer operations. The catalytic N-oxidation of alkylpyridines using hydrogen peroxide as an oxidizing agent is such a process in need of improvement. The N-oxidation reaction is widely used in the pharmaceutical industry; however, a safety issue must be addressed in this process: the very condition-sensitive, undesired decomposition of hydrogen peroxide, which produces oxygen and water. The hazards are related to the generation of oxygen, since it can cause the reaction vessel to over-pressurize and lead to serious explosions and fires when combined with the flammable alkylpyridines. Previous experimental studies on this reaction exist, but the separation of phases in the reaction mixture has hindered the description of the kinetic model that represents the reaction and helps in the prediction of runaway scenarios. In order to overcome the operating limitations and hazardous conditions, a methodology is developed, where phase equilibrium and calorimetric studies are combined. The Gibbs minimization method was used to investigate the phase diagram of an alkylpyridine-water system. Experiments in an adiabatic calorimeter were performed to assess the safety parameters of the N-oxidation of low-order alkylpyridines (picolines). The purpose of this work is to find a new set of operating conditions where the phase separation and decomposition reactions are suppressed. The conditions will be selected based on three important aspects: the viability of performing the operation at an industrial scale, the efficiency of the reaction, and the operational safety under the new conditions.
机译：由于化学品的特性和在异常条件下可能产生的潜在危险情况，化学反应中存在风险。这些反应被用于工业过程中，但是仍然需要改进技术并寻找可导致更安全操作的替代方法。使用过氧化氢作为氧化剂的烷基吡啶的催化N-氧化是需要改进的方法。 N-氧化反应被广泛用于制药工业。但是，在此过程中必须解决安全问题：条件敏感的过氧化氢非常不希望的分解，会产生氧气和水。危害与氧气的产生有关，因为当与易燃的烷基吡啶结合使用时，它可能导致反应容器过压并导致严重的爆炸和燃烧。已有关于该反应的实验研究，但反应混合物中的相分离阻碍了代表反应的动力学模型的描述，并有助于预测失控情况。为了克服操作限制和危险条件，开发了一种方法，将相平衡和量热研究相结合。吉布斯最小化方法用于研究烷基吡啶-水体系的相图。在绝热热量计中进行了实验，以评估低级烷基吡啶（甲基吡啶）N-氧化的安全性参数。这项工作的目的是找到一套新的操作条件，其中相分离和分解反应得到抑制。将基于三个重要方面选择条件：在工业规模上进行操作的可行性，反应效率以及在新条件下的操作安全性。

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  • 会议地点 Tampa FL(US);Tampa FL(US);Tampa FL(US)
  • 作者

    Lina R. Saenz; William J. Rogers; M. Sam Mannan; Maria Papadaki;

  • 作者单位

    Mary Kay O'Connor Process Safety Center Artie McFerrin Department of Chemical Engineering, Texas AM University College Station, Texas 77843-3122, USA;

    Mary Kay O'Connor Process Safety Center Artie McFerrin Department of Chemical Engineering, Texas AM University College Station, Texas 77843-3122, USA;

    Mary Kay O'Connor Process Safety Center Artie McFerrin Department of Chemical Engineering, Texas AM University College Station, Texas 77843-3122, USA;

    Department of Environmental and Natural Resources Management University of Ioannina Seferi 2, Agrinio, GR 30100, Greece;

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