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首页> 外文期刊>Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry >Challenges in the development of an efficient enzymatic process in the pharmaceutical industry
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Challenges in the development of an efficient enzymatic process in the pharmaceutical industry

机译：制药行业高效酶促工艺开发面临的挑战

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摘要

Despite the unparalleled opportunities that have emerged for biocatalysis over the last few years, there still exist challenges that will hinder the development of an efficient enzymatic process in the pharmaceutical industry. The challenges that will be described in this report include the throughput of an enzymatic process, downstream processing issues, and competition from other toolboxes. Perspectives on economic and intellectual property issues as well as the dynamics surrounding drug intermediates that fall into different stages of the overall drug development process will also be highlighted. Finally, literature examples will be used to offer solutions to those barriers faced by enzymatic processes attempting to transition into manufacturing scale. (C) 2004 Elsevier Ltd. All rights reserved.
机译：尽管在过去几年中出现了无与伦比的生物催化机会，但仍然存在一些挑战，这些挑战将阻碍制药行业高效酶促工艺的发展。本报告将描述的挑战包括酶促工艺的通量，下游加工问题以及与其他工具箱的竞争。也将重点介绍对经济和知识产权问题的看法，以及属于整个药物开发过程不同阶段的药物中间体的动态。最后，文献实例将用于为试图转化为生产规模的酶促工艺所面临的那些障碍提供解决方案。 （C）2004 Elsevier Ltd.保留所有权利。

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