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Design, Synthesis and Fungicidal Activity of Pyrazolecarboxamide Compounds

机译:吡唑甲酰胺类化合物的设计,合成及杀真菌活性

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摘要

@@ Tolfenpyrad, a commercialized Pyrazolecarboxamide Derivatives, shows good insecticidal/acaricidal activity against Lepidoptera, Hemiptera, Thysanoptera and eriophyid mites in vegetables, ornamentals and fruit, also active against the fungus Sphaerotheca fuliginea. By using the intermediate derivatization method, an important intermediate (4-(pyridin-2yloxy) phenyl) alkylamines were synthesized starting from (un) substituted 2-halopyridine and phenols containing cyano such as 4-hydroxybenzonitrile, 2-( 4-hydroxyphenyl) acetonitrile and 3-(4-hydroxyphenyl ) propanenitrile, to replace the corresponding part of Tolfenpyrad. A series of Pyrazolecarboxamide Derivatives were synthesized and bioassayed. The structure-activity relationships of the synthesized compounds were also discussed.
机译:Tolfenpyrad,一种商业化的吡唑甲酰胺衍生物,对蔬菜,观赏植物和水果中的鳞翅目,半翅目,Th翅目和类鳞螨具有良好的杀虫/杀螨活性,也对Sphaerotheca fuliginea真菌有效。通过中间衍生化方法,从(未)取代的2-卤吡啶和含有氰基的酚(例如4-羟基苄腈,2-(4-羟基苯基)乙腈)合成了重要的中间体(4-(吡啶-2-基氧基)苯基)烷基胺和3-(4-羟苯基)丙腈,以取代托芬吡拉德的相应部分。合成了一系列吡唑甲酰胺衍生物并进行了生物分析。还讨论了合成化合物的构效关系。

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