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首页> 外文会议>Proceedings of the ASME international mechanical engineering congress and exposition 2009 >HIGH-FREQUENCY ULTRASOUND TISSUE CLASSIFICATION OF ATHEROSCLEROTIC PLAQUES IN AN APOE-KO MOUSE MODEL USING SPECTRAL ANALYSIS
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HIGH-FREQUENCY ULTRASOUND TISSUE CLASSIFICATION OF ATHEROSCLEROTIC PLAQUES IN AN APOE-KO MOUSE MODEL USING SPECTRAL ANALYSIS

机译：基于谱分析的APOE-KO小鼠模型中动脉粥样硬化斑块的高频超声组织分类

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摘要

Small animal models have been widely used in cardiovascular research when studying the development and treatment of different diseases. This kind of research has promoted the development of noninvasive techniques to assess cardiac tissue and blood vessels of small animals. Recently, we have developed a high-frequency ultrasound imaging system for small animals, in particular, mouse and rat models. In this work, we aim to elucidate the usefulness of using spectral analysis of the received radiofrequency (RF) ultrasound signals to extract quantitative parameters to assess mechanical properties of cardiac and vascular tissues. A custom system that employs high-frequency single-element ultrasound transducers (30-120 MHz) is used for scanning. Various signal and image processing techniques are applied on the received ultrasound signals to reconstruct high resolution B-mode and spectral images. In vitro imaging of isolated heart and vessels of APOE-KO "knock-out" mouse model with atherosclerosis was performed. Power spectral densities (PSD) of RF signals were evaluated within various regions of interests (ROI) including degassed water, normal cardiac tissue, and cardiac tissue with atheroma. Various parameters were extracted from the power spectrum such as the maximum power (P_(max)), the frequency at maximum power (F_(peak)), and the variance of power spectrum (P_(var)). Results of the preliminary spectral analysis indicated larger values for the P_(max), F_(peak) and P_(var) parameters for ROI contains atheroma than other regions. For example using the envelop data, the normalized maximum power (P_(max)) value for cardiac tissue with atheroma was 0.0 ± 0.789 (dB), whereas for normal tissues it was about -13.71± 0.267 (dB). These results suggest the use spectral images as a quantitative method when assessing mouse hearts and blood vessels noninvasively.
机译：在研究不同疾病的发展和治疗时，小型动物模型已广泛用于心血管研究。这种研究促进了评估小动物心脏组织和血管的非侵入性技术的发展。最近，我们为小型动物，尤其是小鼠和大鼠模型开发了高频超声成像系统。在这项工作中，我们旨在阐明使用接收到的射频（RF）超声信号的频谱分析来提取定量参数以评估心脏和血管组织的机械特性的有用性。使用高频单元素超声换能器（30-120 MHz）的定制系统用于扫描。将各种信号和图像处理技术应用于接收到的超声信号，以重建高分辨率B模式和频谱图像。对患有动脉粥样硬化的APOE-KO“敲除”小鼠模型的离体心脏和血管进行了体外成像。在各个目标区域（ROI）内评估了RF信号的功率谱密度（PSD），这些区域包括脱气水，正常心脏组织和患有动脉粥样硬化的心脏组织。从功率谱中提取了各种参数，例如最大功率（P_（max）），最大功率下的频率（F_（peak））和功率谱的方差（P_（var））。初步光谱分析的结果表明，ROI的P_（max），F_（peak）和P_（var）参数的值比其他区域更大。例如，使用包络数据，患有动脉粥样硬化的心脏组织的标准化最大功率（P_（max））值为0.0±0.789（dB），而对于正常组织则约为-13.71±0.267（dB）。这些结果表明，在无创评估小鼠心脏和血管时，应使用光谱图像作为定量方法。

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