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首页> 外文会议>Proceedings of Life in space for life on earth >ESA IBER-2: MOLECULAR AND CELLULAR CHANGES IN HUMAN ENDOTHELIAL CELLS IN RESPONSE TO NICKEL ION IRRADIATION (CORALS PROJECT)
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ESA IBER-2: MOLECULAR AND CELLULAR CHANGES IN HUMAN ENDOTHELIAL CELLS IN RESPONSE TO NICKEL ION IRRADIATION (CORALS PROJECT)

机译：ESA IBER-2：人类内皮细胞对镍离子辐照的分子和细胞变化（珊瑚项目）

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摘要

On Earth, most radiation exposures (medical and naturalrnbackground) consist of low-linear energy transfer (LET)rnphotons. In space, astronauts are exposed to higherrndoses and to more varied types of radiation. Cosmicrnradiation mainly consists of high-energy protons andrnhigh-Z and -energy (HZE) particles. These high-LETrnparticles are predicted to account for most of thernradiation induced health effects. In this regard, furtherrnanalysis of the biological effects of HZE particles isrnessential. In the present study, endothelial cells werernirradiated with different doses of nickel ions producedrnin the synchrotron at GSI (Darmstadt, Germany). Afterrndifferent time points, RNA was extracted for genomewidernanalysis and supernatants were collected forrnmultiplex cytokine assay. DNA double strand breaksrnwere detected using γH2AX staining. Our resultsrndemonstrated that nickel irradiation induced molecularrnand cellular changes in human endothelial cells. Furtherrnanalysis is ongoing to confirm the obtained data and tornfurther explore the biological effects after nickel ionrnexposure.
机译：在地球上，大多数辐射暴露（医学和自然背景）由低线性能量转移（LET）rn光子组成。在太空中，宇航员会受到更高剂量和多种辐射的影响。宇宙辐射主要由高能质子和高Z和高能（HZE）粒子组成。预计这些高LETrn粒子会解释大多数辐射诱发的健康影响。在这方面，进一步分析HZE颗粒的生物学效应是必要的。在本研究中，在GSI（德国达姆施塔特）的同步加速器中，用不同剂量的镍离子辐照了内皮细胞。在不同时间点之后，提取RNA用于全基因组分析，并收集上清液用于多重细胞因子测定。使用γH2AX染色检测DNA双链断裂。我们的结果表明，镍辐照诱导人内皮细胞的分子和细胞变化。正在进行进一步的分析以确认所获得的数据，并进一步探讨镍离子暴露后的生物学效应。

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  • 会议地点 Aberdeen(GB)
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    M. Moreels; R. Quintens; W. De Vos; M. Beck; K. Tabury; A. Suetens; K. Abouelaradat; B.Dieriks; E. Ernst; R. Lee; C. Lambert; P. Van Oostveldt; S. Baatout;

  • 作者单位

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium. E-mail: mmoreels@sckcen.be;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

    Lab of Connective Tissues Biology, University of Liège, Tour de Pathologie B23/3, 4000 Liège, Belgium;

    Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany;

    Lab of Connective Tissues Biology, University of Liège, Tour de Pathologie B23/3, 4000 Liège, Belgium;

    Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

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