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首页> 外文会议>Proceedings of Life in space for life on earth >VENTRICULAR REPOLARIZATION ADAPTATION TO ABRUPT CHANGES IN HEART RATE AFTER MICROGRAVITY SIMULATION BY 5-DAY HEAD-DOWN BED REST
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VENTRICULAR REPOLARIZATION ADAPTATION TO ABRUPT CHANGES IN HEART RATE AFTER MICROGRAVITY SIMULATION BY 5-DAY HEAD-DOWN BED REST

机译：通过5天平躺式床架的微观重力模拟后心室再极化适应心率的急剧变化

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摘要

Microgravity exposure for long periods of time leads tornbody deconditioning and it increases the risk of experiencingrnlife-threatening arrhythmias. The study of ventricularrnrepolarization dependence on heart rate has beenrnused to stratify patients according to their arrhythmic risk.rnThe QT_p adaptation to HR changes is characterized byrnM_(90) (90% of the adaptation). The QT_p=HR, after compensationrnfor the adaptation lag, is modeled using a set ofrnregression functions (a, kind of slope of relationship).rnSubjects with lower orthostatic tolerance time showed arnnon significant decrease in the adaptation lag (M90 fromrn148 to 108 beats), which may be due to an extra deconditioningrnin the sympathovagal response. Nevertheless anrnincrease in the QT_p=HR adaptation lag (M90 from 108 torn117 beats with a p = 0.06) and a significant reduction inrnthe slope (a from 0.53 to 0.35 with a p < 0.005), which inrnprevious studies have been correlated with an increasedrnarrhytimic risk, were observed for subjects with higherrnorthostatic tolerance time.
机译：长时间暴露于微重力下会导致身体残损，并增加发生威胁生命的心律失常的风险。根据心律失常风险对心室复极化对心率的依赖性进行了研究，以对患者进行分层。rnQT_p对HR变化的适应性以rnM_（90）（90％的适应性）为特征。 QT_p = HR，在对适应滞后进行补偿后，使用一组回归函数（a，一种关系斜率）进行建模。体位耐受时间较低的受试者显示，适应滞后明显减少（M90从rn148降至108拍），这可能是由于交感迷走神经反应中额外的失调所致。然而，QT_p = HR适应性滞后增加（M90从108撕裂117次搏动，p = 0.06）和斜率显着降低（a从0.53降低至0.35，p <0.005），这是以前的研究与增加的心律失常风险相关的观察到正直耐受时间较高的受试者。

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  • 会议地点 Aberdeen(GB)
  • 作者

    J. Bolea; R. Almeida; E. Pueyo; P. Laguna; E.G. Caiani;

  • 作者单位

    Communications Technology Group (GTC), Aragón Institute of Engineering Research (I3A), IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain CIBER - Bioingeniería, Biomateriales y Nanomedicina, Zaragoza, Spain;

    Communications Technology Group (GTC), Aragón Institute of Engineering Research (I3A), IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain CIBER - Bioingeniería, Biomateriales y Nanomedicina, Zaragoza, Spain Centro de Matemática Aplicada da Universidade do Porto (CMUP), Univ. do Porto, Porto, Portugal;

    CIBER - Bioingeniería, Biomateriales y Nanomedicina, Zaragoza, Spain Communications Technology Group (GTC), Aragón Institute of Engineering Research (I3A), IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain;

    Communications Technology Group (GTC), Aragón Institute of Engineering Research (I3A), IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain CIBER - Bioingeniería, Biomateriales y Nanomedicina, Zaragoza, Spain;

    Biomedical Eng. Dpt., Politecnico di Milano, Milan, Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    ventricular repolarization; QT dynamics; QT/RR hysteresis; arrhythmic risk;

    机译：心室复极; QT动态; QT / RR滞后;心律失常风险;

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