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首页> 外文期刊>Physiological measurement >Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization
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Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization

机译：在头向下卧床休息固定诱导的T波障碍方面评估心室复极不稳定

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Objective: To assess the effects of different durations of simulated microgravity exposure on ventricular repolarization (VR) in terms of T-wave alternans (TWA) as well as to test whether an increase in VR heterogeneity could be detected once normal gravity was restored. Approach: A total of 63 healthy volunteers were recruited in several head-down bed-rest (HDBR) experiments in the context of the European Space Agency bed-rest strategy. TWA is evaluated during the night period using ambulatory ECG recordings, before, during and after long- (60 d), mid- (21 d) and short- (5 d) duration HDBR by the long-term averaging technique. Main results: 5-21 d of exposure to simulated microgravity by means of the HDBR model do not lead to a significant increase of cardiac electrical instability in healthy myocardial substrates up to the point of eliciting TWA on the surface ECG. However, TWA indices increased after long-term HDBR exposure, once normal gravity was re-established, indicative of incipient electrical instability on VR at the conclusion of 60 d of HDBR. Significance: The results of this work underline the importance of focusing future research on immediate effects after long-term microgravity exposure, both simulated by HDBR or from space mission scenarios, once partial gravity conditions are re-established. A deeper insight in the understanding of human body reactions in these scenarios results crucial in the design of future longduration spaceflight missions, to mitigate any potential risk that can limit astronaut's performance.
机译：目的：评估模拟微抗痛暴露对腔内复极化（VR）的不同持续时间对T波段（TWA）的影响，以及测试是否恢复正常重力一旦恢复正常重力就可以检测到VR异质性的增加。方法：在欧洲航天局床站休息策略的背景下，共招募了63个健康的志愿者，在几个下落的床休息（HDBR）实验中。在长期平均技术的长期平均技术的长期（60d），中间（21d），中间（21d）和短（5 d）持续时间hdbr之前，在夜间评估TWA。主要结果：5-21天通过HDBR模型暴露于模拟的微匍匐性，不会导致健康心肌基质中的心脏电不稳定性的显着增加，直至表面心电图诱导TWA。然而，在长期HDBR暴露后，TWA指数增加，一旦重新建立正常重力，表明在60d的HDBR结束时对VR的初始电不稳定性。意义：这项工作的结果强调了在长期微重力暴露后重点关注未来研究的重要性，包括HDBR或空间任务情景，一旦重新建立了部分重力条件。在这些情景中对人体反应的理解深入了解，在这些情景中的设计至关重要，在未来的漫长空间航天特派团的设计中，减轻了可能限制宇航员性能的任何潜在风险。

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