• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Proceedings of the 2016 IEEE ANDESCON >Design and analysis of microneedles structures for transdermal drug delivery
【24h】

Design and analysis of microneedles structures for transdermal drug delivery

机译：设计和分析用于透皮给药的微针结构

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this paper we present the designs and analysis of different shapes of microneedles. We determined which one is the most appropriate for transdermal drug delivery purposes. The 450 μm microneedles length as long as their 70 μm outer diameter and 26 μm inner diameter measures allowed us to reduce the loss factor at the moment of the insertion into the skin; also to be undetectable to the human nerve system reaching only up to the epidermis. Analysis and simulation of microneedles were performed using ANSYS Finite Element Analysis (FEA) tool, to determine the shape that reduces the most all stresses caused during the skin piercing process. Microneedles simulations results were conclusive indicating that the stresses due to the applied loads were under the yield strength of the set of hardened materials, such as Nickel (Ni), Silicon Carbide (SiC) and Silica (SiO2).
机译：在本文中，我们介绍了不同形状的微针的设计和分析。我们确定了哪一种最适合经皮给药。 450微米的微针长度（只要其外径为70微米，内径为26微米）使我们能够减少插入皮肤时的损耗因子。还不能被人类神经系统检测到仅到达表皮。使用ANSYS有限元分析（FEA）工具进行了微针的分析和模拟，以确定可以减少皮肤穿刺过程中产生的所有应力的形状。微针模拟结果是结论性的，表明由于施加的载荷而产生的应力在一组硬化材料（例如镍（Ni），碳化硅（SiC）和二氧化硅（SiO2））的屈服强度以下。

著录项

  • 来源
  • 会议地点 Arequipa(PE)
  • 作者

    Jennifer García; Ismael Rios; Faruk Fonthal;

  • 作者单位

    Advanced Materials for Micro and Nanotechnology Research Group - IMAMNT, Universidad Autónoma de Occidente, Cali, Colombia;

    Advanced Materials for Micro and Nanotechnology Research Group - IMAMNT, Universidad Autónoma de Occidente, Cali, Colombia;

    Advanced Materials for Micro and Nanotechnology Research Group - IMAMNT, Universidad Autónoma de Occidente, Cali, Colombia;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Stress; Skin; Drug delivery; Force; Shape; Nickel; Silicon carbide;

    机译：应力;皮肤;药物输送;力;形状;镍;碳化硅;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号