Biomarkers, a new tool for process control in maltingand brewing

机译：生物标志物，麦芽和酿造过程控制的新工具

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Systems biology is a "new" field in life sciences. One element of systems biology relates tornthe massive collection of data on all the biochemical processes in a living cell. The expressionrnlevel of all the genes can be measured using DNA chips, a significant part of all proteins canrnbe identified and quantified by proteomic methods, and a large number of the metabolitesrnmeasured using combinations of chromatography and mass spectrometry This analyticalrnexercise is expensive, laborious and certainly not adaptable to routine use. However, from thisrnmassive amount of data a limited number of parameters can be identified which are predictivernfor a certain chain of events. These parameters, I.e. biomarkers, may combine expressionrnpatterns, proteins and metabolites. Robust and affordable tools can be developed to measurernthese specific markers. Early observation of a shift in the physiological state of bothrngerminating barley and of yeast should help to better control the processes in both maltingrnand brewing. However, a significant research input is required to identify relevantrnbiomarkers.

机译：系统生物学是生命科学的“新”领域。系统生物学的一个要素涉及大量收集活细胞中所有生化过程的数据。可以使用DNA芯片测量所有基因的表达水平，可以通过蛋白质组学方法鉴定和定量所有蛋白质的重要部分，并使用色谱和质谱联用方法测量大量的代谢物。这种分析方法昂贵，费力且肯定不会适应常规使用。但是，从海量数据中，可以确定数量有限的参数，这些参数对于某些事件链是可预测的。这些参数，即生物标志物，可以结合表达模式，蛋白质和代谢产物。可以开发健壮且负担得起的工具来测量这些特定标记。早期观察发芽的大麦和酵母的生理状态发生变化应有助于更好地控制麦芽制造和酿造过程。然而，需要大量的研究投入来鉴定相关的生物标志物。

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来源
《Proceedings of the 30th EBC congress (Prague 2005)》|2005年|134-139|共6页
会议地点 Prague (CS)
作者
Hans S?derlund; Matej Orěsiě; Kari Kataja; Reetta Satokari; Timo Pulli; Kristiina Takkinen; Silja Home;
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VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland (e-mail:rnhans.soderlund@vtt.fi);

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

VTT Biotechnology, P.O. Box 1500, FI-02044 VTT, Finland;

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正文语种 eng
中图分类酿酒工业;
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Biomarkers, a new tool for process control in maltingand brewing

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