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首页> 外文会议>Progress in functional amino acids and carbohydrates for animal production >A Preliminary Study on Developmental Changes of Metabonome in Serum of Suckled Piglets by an NMR-based Metabonomic Approach
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A Preliminary Study on Developmental Changes of Metabonome in Serum of Suckled Piglets by an NMR-based Metabonomic Approach

机译：基于NMR的代谢组学方法研究乳猪血清中代谢组学的发育变化

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摘要

This study was conducted to determine the developmental changes of metabonome in serum of suckled piglets using 1H Nuclear Magnetic Resonance (1H NMR) spectrometry. 18 naturally suckled crossbred piglets (Duroc × Landrace × Yorkshine) were selected and blood samples were taken from jugular vein (10ml) at the ages of d 1, 7, and 21 after brith, respectively. The result showed 53 kinds of small molecule metabolites in serum of suckled piglets were detected with the age of growth, and energy metabolism and protein metabolism were in preference to fat metabolism in piglets. Key words: Serum, Metabonome, 1H NMR, Suckled piglets Biochemical changes in blood may reflect the tissue cells permeability change and the function of the body metabolic change. Metabolism is the total (bio)chemical changes in living organisms and metabolic activities are the basic features of living systems. Metabonome is the dynamic complement of the endogenous metabolites within the integrated biological systems (Tang and Wang, 2006). Nutritional intake may be natural lead to changes in endogenous metabolism of body, the changes are often be thought from the degree of ease, if only for a limited number of indicators to measure metabolic analysis may be difficult to capture such changes in metabolism, but if the Metabolic analysis of the overall group, it has greatly increased the information to capture the possibility of such a change (Tang and Wang, 2007). Metabolomics blood contains cells of each animal's metabolism information (including the host and bacteria), also contains interaction between a host of metabolic activity and flora (Hooper and Gordon, 2001; Xu, et al., 2003; Nicholson, et al., 2003, 2004,2005,2006), therefore, metabolomics study is the main metabolic path as a substrate and composition of metabolites of small molecule (MW <1000), through the study of metabonomics, can be a better understanding of blood metabolites change trends in developmental suckled piglets.
机译：这项研究是用1H核磁共振（1H NMR）光谱法测定乳猪血清中代谢组的发育变化的。选择18头天然哺乳的杂种仔猪（Duroc×Landrace×Yorkshine），并分别在出生后第1、7和21岁时从颈静脉（10ml）中采血。结果表明，随着年龄的增长，乳猪血清中检测到53种小分子代谢物，能量代谢和蛋白质代谢优先于脂肪代谢。关键词：血清，代谢组，1H NMR，乳猪血液中的生化变化可能反映了组织细胞的通透性变化和人体代谢功能的变化。代谢是生命有机体的全部（生物）化学变化，代谢活动是生命系统的基本特征。代谢组学是整合生物系统中内源性代谢物的动态补充（Tang and Wang，2006）。营养摄入可能是自然导致体内内源性代谢变化的因素，人们通常从缓解程度考虑变化，如果仅对有限数量的指标进行代谢分析，可能难以捕捉到这种代谢变化，但如果通过对整个群体的代谢分析，它极大地增加了信息以捕获这种变化的可能性（Tang and Wang，2007）。代谢组学血液包含每只动物的细胞代谢信息（包括宿主和细菌），还包含宿主的许多代谢活性与菌群之间的相互作用（Hooper和Gordon，2001； Xu等，2003； Nicholson等，2003） （2004,2005,2006），因此，代谢组学研究是代谢的主要途径，是小分子代谢产物（MW <1000）的底物和组成，通过代谢组学的研究，可以更好地了解血液代谢产物的变化趋势。发育性乳猪。

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  • 来源
  • 会议地点 Guangzhou(CN)
  • 作者

    T.J.Li; Q.He; X.Wu; K.Yao; W.C.Wang; R.L.Huang; Y.L.Yin;

  • 作者单位

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

    Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 饲料;
  • 关键词

    Serum; Metabonome; 1H NMR; Suckled piglets;

    机译：血清;代谢组学; 1 H NMR;乳猪;

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