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首页> 外文会议>Progress in Electromagnetics Research Symposium - Fall >Influence of media type on heating of selected magnetic nanoparticles with time-harmonic magnetic fields
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Influence of media type on heating of selected magnetic nanoparticles with time-harmonic magnetic fields

机译：介质类型对时谐磁场对选定磁性纳米粒子加热的影响

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Hyperthermia is already well established in cancer treatment as a sensitizer to radiotherapy and chemotherapy. It is based on heating of tumor area to temperatures between 41 and 45°C. Usually it is induced by electromagnetic or ultrasound waves. In both cases selective heating of the treated area is accomplished by superposition of fields and is due to physical and technical limitations a challenging task. A very promising concept for preferential heating of the tumor area is based on accumulation of magnetic nanoparticles in the tumor and heating them with time-harmonic magnetic fields. In this work we use 1 ml sample of four different magnetic nanoparticles with different cores and coatings dispersed in PBS and deionized water. The individual samples were exposed to a time-harmonic magnetic field and the sample temperature was monitored throughout the exposure. The concentration of nanoparticles in the samples was chosen to correspond to realistic values that may be present in biological tissues without being toxic. For this purpose, we designed and manufactured an exposure system operating at 200 kHz. The exposure time was set to 5 minutes and the amplitude of the applied magnetic field intensity was up to 5 kA ·m
机译：在癌症治疗中，高温疗法已成为放射疗法和化学疗法的敏化剂。它基于将肿瘤区域加热到41至45°C之间的温度。通常，它是由电磁波或超声波引起的。在这两种情况下，治疗区域的选择性加热都是通过场的叠加来实现的，并且由于物理和技术限制，这是一项艰巨的任务。优先加热肿瘤区域的非常有前途的概念是基于磁性纳米颗粒在肿瘤中的积累，并利用时谐波磁场对其进行加热。在这项工作中，我们使用1 ml的四种不同磁性纳米颗粒样品，这些颗粒具有分散在PBS和去离子水中的不同核和涂层。将单个样品暴露于时间谐波磁场，并在整个暴露过程中监测样品温度。选择样品中纳米颗粒的浓度以对应于可能存在于生物组织中且无毒的实际值。为此，我们设计并制造了工作在200 kHz的曝光系统。曝光时间设置为5分钟，施加的磁场强度的幅度最大为5 kA·m

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