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首页> 外文会议>Progress on post-genome technologies and modern natural products >CYTOTOXIC INTERATIVE EFFECTS OF CONSTITUENTS FROM RHIZOMA COPTIS
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CYTOTOXIC INTERATIVE EFFECTS OF CONSTITUENTS FROM RHIZOMA COPTIS

机译：根瘤菌成分的细胞毒性相互作用

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摘要

Generally, alkaloids, especially berberine(ber), were considered as the main toxic compounds in Rhizoma Coptis(RC). Little attention were paid to investigate the toxicity interactive effect of constituents in RC. The present study was designed to conduct cytotoxic interactive effects of compounds in HepG2 cells. Palmatine(1), coptisine(2), epiberberine (3), jatrorrhizine(4), and ferulic acid(5), which occupied high percentage in RC, were used to investigate the interaction with berberine. The quantitative analysis of compounds 1-5 and berberine were perform by HPLCDAD. The combination of alkaloids matching the original percentage (cas) and the combination of acid-alkaline pair medicine consisting of ferulic acid and berberine matching the original percentage (cfb) showed obvious attenuated effect, compared to same dose of berberine, respectively. The result suggested the combination of constituents was beneficial to attenuating the toxicity of RC.
机译：通常，生物碱，特别是小ber碱（berberine（ber））被认为是黄连中的主要有毒化合物。很少有人注意研究RC中各成分的毒性相互作用。本研究旨在进行HepG2细胞中化合物的细胞毒性相互作用。使用帕马汀（1），黄连（2），表皮小ine碱（3），麻风树碱（4）和阿魏酸（5）（在RC中占很高的百分比）来研究与小ber碱的相互作用。通过HPLCDAD进行化合物1-5和小ber碱的定量分析。与相同剂量的小ber碱相比，分别与原始比例（cas）匹配的生物碱组合和由阿魏酸和小ber碱组成的酸碱配对药物组合（cfb）显示出明显的减弱作用。结果表明，成分的组合有利于减轻RC的毒性。

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  • 来源
  • 会议地点 Chongqing(CN)
  • 作者

    Chen Hongying; Ye Xiaoli; Jin Yanan; Jing Huang; Chen Zhu; Li Xuegang;

  • 作者单位

    School of Life and Engineering, Southwest University of Science and Technology, Mianyang 621010, China School of Pharmacy, Southwest University, Chongqing 400716, China;

    School of Life Science, Southwest University, Chongqing 400716, China;

    School of Life and Engineering, Southwest University of Science and Technology, Mianyang 621010, China;

    School of Life and Engineering, Southwest University of Science and Technology, Mianyang 621010, China;

    School of Life and Engineering, Southwest University of Science and Technology, Mianyang 621010, China;

    School of Life and Engineering, Southwest University of Science and Technology, Mianyang 621010, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学（生物技术）;
  • 关键词

    Rhizoma Coptis; Cytotoxity; MTT; berberinej alkaloids;

    机译：黄连;细胞毒性； MTT；小ber碱生物碱;

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