APPLICATION OF MAGNETIC NANOPARTICLES IN HIGH-THROUGHPUT SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) AND COPY NUMBER VARIATIONS (CNVs) ANALYSIS

机译：磁性纳米粒子在高通量单核苷酸多态性（SNPs）和拷贝数变异（CNVs）分析中的应用

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In the last decade, we have been investigating some novel approaches by which high-throughput single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) analysis can be realized with the help of magnetic nanoparticles, especially for the simultaneous detection of multiplex loci for a number samples. In this review paper, we retrospectively introduce the advances for the research and give some expectation in the near future.

机译：在过去的十年中，我们一直在研究一些新颖的方法，借助这些方法，可以借助磁性纳米颗粒实现高通量单核苷酸多态性（SNP）和拷贝数变异（CNV）分析，尤其是用于同时检测多态性基因位点。一些样本。在这篇综述文件中，我们回顾性地介绍了这项研究的进展，并在不久的将来给出了一些期望。

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来源
《Progress on post-genome technologies and modern natural products》|2011年|24-26|共3页
会议地点 Chongqing(CN)
作者
He Nongyue;
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作者单位

State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China Hunan Key Laboratory of Green Packaging and Application of Biological Nanotechnology, Hunan University of Technology, Zhuzhou 412008, China;

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会议组织
原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词
Magnetic nanoparticles; Single nucleotide polymorphisms; Copy number variations; High-throughput;

机译：磁性纳米粒子；单核苷酸多态性；复制号码的变化；高通量;

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1. The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease [J] . Liu Jiaqi, Zhou Yangzhong, Liu Sen, Human Genetics . 2018,第6a7期

机译：在轨迹处的拷贝数变异（CNV）和单核苷酸多态性（SNP）的共存可能导致将SNP与疾病相关的重要性扭曲
2. PCR amplification on magnetic nanoparticles: Application for high-throughput single nucleotide polymorphism genotyping [J] . Hongna Liu, Song Li, Zhifei Wang, Biotechnology Journal: Healthcare,Nutrition,Technology . 2007,第4期

机译：磁性纳米粒子的PCR扩增：高通量单核苷酸多态性基因分型的应用
3. High-Throughput RNA-Seq Data Analysis of the Single Nucleotide Polymorphisms (SNPs) and Zygomorphic Flower Development in Pea ( Pisum sativum L.) [J] . Keyuan Jiao, Shihao Su, Xin Li, International Journal of Molecular Sciences . 2017,第12期

机译：豌豆（Pisum sativum L.）单核苷酸多态性（SNPs）和合子形花发育的高通量RNA-Seq数据分析
4. Detection of Single Nucleotide Variations and Copy Number Variations in Breast Cancer Samples Using Single Nucleotide Polymorphism-Targeted Massively Multiplexed PCR [C] . Zachary Demko, Bernhard G. Zimmermann, Eser Kirkizlar, International Molecular Medicine Tri-Conference. . 2015

机译：使用单核苷酸多态性靶向大规模多重PCR检测单核苷酸变化和乳腺癌样品的拷贝数变化
5. Global views of human genetic variation: Single -nucleotide polymorphisms' (SNPs) effects and their random nature [D] . Mosley, Coleman A. 2006

机译：人类遗传变异的全球观点：单核苷酸多态性'（SNPS）效应及其随机性
6. The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease [O] . Jiaqi Liu, Yangzhong Zhou, Sen Liu, -1

机译：拷贝数变异（CNV）和单核苷酸多态性（SNP）在一个基因位点的共存会导致将SNP与疾病关联的重要性的计算错误
7. The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease [O] . Jiaqi Liu, Yangzhong Zhou, Sen Liu, 2018

机译：在轨迹处的拷贝数变异（CNV）和单核苷酸多态性（SNP）的共存可能导致将SNP与疾病相关的重要性扭曲

APPLICATION OF MAGNETIC NANOPARTICLES IN HIGH-THROUGHPUT SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) AND COPY NUMBER VARIATIONS (CNVs) ANALYSIS

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