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Targeting tumor metabolism: novel strategies against cancer stem cells? New aspects and changing paradigms

机译：靶向肿瘤代谢：抗癌干细胞的新策略？新的方面和不断变化的范例

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摘要

Novel evidence suggests there could be more to metabolism than meets the eye at first impression. A newly discovered link between metabolic changes and differentiation has intriguing connections to an old hypothesis advocated by Otto Warburg for tumor metabolism. As stem cells are predominantly reliant on glycolytic metabolism, which may be applicable to cancer stem cells, new metabolism findings could constitute a vantage point for cancer research. If these concepts and interconnections between metabolism and cellular differentiation can be further substantiated in solid malignancies and apply to cancer initiating cells, our view on cancer may significantly change, which may alter future therapeutic strategies.
机译：新颖的证据表明，新陈代谢可能比第一眼看到的更多。新近发现的代谢变化和分化之间的联系与奥托·沃伯格（Otto Warburg）提倡的关于肿瘤代谢的旧假设有着令人感兴趣的联系。由于干细胞主要依赖于糖酵解代谢，这可能适用于癌症干细胞，因此新的代谢发现可能构成癌症研究的有利条件。如果这些概念以及新陈代谢与细胞分化之间的相互联系可以在实体恶性肿瘤中得到进一步证实，并应用于癌症引发细胞，那么我们对癌症的看法可能会发生重大变化，从而可能改变未来的治疗策略。

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  • 会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
  • 作者

    DEREK ZIEKER; INGMAR KOENIGSRAINER; RUSSELL S. TAICHMAN; MARKUS LOEFFLER;

  • 作者单位

    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Hoppe-Seyler-Str.3, D-72076 Tuebingen, GERMANY,Institute of Clinical and Experimental Transfusion Medicine, University of Tuebingen, Otfried-Mueller-Str. 4/1, D-72076 Tuebingen, GERMANY;

    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Hoppe-Seyler-Str.3, D-72076 Tuebingen, GERMANY;

    Department of Periodontics and Oral Medicine, University of Michigan, School of Dentistry, Ann Arbor, Michigan, 1101 N. University Ave, Ann Arbor, MI 48109-1078, USA.;

    Department of General, Visceral and Transplant Surgery, Comprehensive Cancer Center, University of Tuebingen, Hoppe-Seyler-Str.3, D-72076 Tuebingen, GERMANY,Institute of Clinical and Experimental Transfusion Medicine, University of Tuebingen, Otfried-Mueller-Str. 4/1, D-72076 Tuebingen, GERMANY;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    cancer stem cells; cancer initiating cells tumor metabolism; differentiation; differentiation therapy; cancer treatment;

    机译：癌症干细胞癌症引发细胞肿瘤代谢；分化分化疗法；癌症治疗;

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