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Tracheobronchopathia Osteochondroplastica: Presentation of Ten Cases and Review of the Literature

机译：气管支气管炎Osteochondroplastica：十例病例介绍和文献复习

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Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease of the endobronchial system with nonspecific symptoms and different treatment approaches. We report on a group of patients with TO and discuss their presentation and their treatment modalities. Between 2000 and 2006, the medical records of patients with TO were studied at the Interventional Pulmonary Unit of the Tracheal Disease Research Center at Masih Daneshvary Hospital, a referral center for respiratory diseases in Tehran, Iran. We analyzed and studied patients' demographics, symptom presentation, radiographic appearance, bronchoscopic findings, and their subsequent treatment. Of the 8760 patients who underwent flexible bronchoscopy (FOB) at our center over 6 years, 10 were diagnosed with TO; their median age was 51 years (range = 16—68 years) and 6 were men. Computerized tomography (CT) revealed mucosal irregularity and calci- fied nodules. Histopathologic examination of tissue biopsy through bronchoscopy was used for definitive diagnosis of TO. Bronchoscopy findings showed the endobronchial lesions to be firm and glossy. Cartilaginous nodules were present in central airways. Treatment included endobronchial Nd:YAG laser photoevaporation (LPE) (n = 10), coring of the lesions with the tip of the rigid bronchoscope (n = 4), and endobronchial stent placement (n = 1). Symptoms were considerably relieved in six cases but there was no significant improvement noted in three patients. One patient died after 6 years of treatment and follow-up. TO is a rare disease and the diagnosis should be suspected based on CT findings or bronchoscopic examination of the airways. Histopathologic examination is required for con- firmation of diagnosis. Treatment is palliative and it includes LPE, coring through a rigid bronchoscope, and endobronchial stent placement.
机译：气管支气管疾病osteochondroplastica（TO）是一种罕见的支气管内系统良性疾病，具有非特异性症状和不同的治疗方法。我们报告了一群TO患者，并讨论了他们的表现和治疗方式。在2000年至2006年之间，在伊朗德黑兰呼吸疾病转诊中心Masih Daneshvary医院气管疾病研究中心的介入性肺科研究了TO患者的病历。我们分析并研究了患者的人口统计学，症状表现，影像学表现，支气管镜检查结果及其后续治疗。在我们中心进行了6年以上的柔性支气管镜检查（FOB）的8760例患者中，有10例被诊断为TO；他们的中位年龄为51岁（范围为16-68岁），其中6名是男性。电脑断层扫描（CT）显示粘膜不规则和结节结节。通过支气管镜对组织活检进行组织病理学检查，以明确诊断TO。支气管镜检查发现支气管内病变牢固而有光泽。中央气道中存在软骨结节。治疗包括支气管内Nd：YAG激光光蒸发（LPE）（n = 10），用硬支气管镜的尖端对病变进行取芯（n = 4）以及支气管内支架置入（n = 1）。 6例症状明显缓解，但3例没有明显改善。经过6年的治疗和随访，一名患者死亡。 TO是一种罕见的疾病，应根据CT表现或气道支气管镜检查怀疑诊断。为了确诊，需要进行组织病理学检查。治疗是姑息性的，包括LPE，通过刚性支气管镜取芯以及放置支气管内支架。

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