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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Pathology >Tracheobronchopathia osteochondroplastica: two cases and a review of the literature
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Tracheobronchopathia osteochondroplastica: two cases and a review of the literature

机译：气管支气管病骨软骨增生：两例并文献复习

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Introduction: Tracheobronchopathia osteochondroplastica (TO) is a rare disorder involving the lumen of the trachea-bronchial tree and characterized by multiple sub-mucosal osseous and cartilaginous nodules in the trachea and bronchus, sparing the posterior wall. We here report two cases of patients with tracheobronchopathia osteochondroplastica and review the relevant literature briefly. Case presentation: Case 1 was a 64-year-old woman with a history of Chronic Obstructive Pulmonary Disease (COPD) who presented with frequent non-productive cough for 2 years. Chest computed tomography (CT) showed signs consistent with COPD and evident irregular narrowing of the tracheal and both main bronchial lumen caused by calcific foci. Fibre optic bronchoscope (FOB) was performed and showed dozens of sub-mucosal nodules protruding into the lumen of lower half of the trachea and both main bronchi. Histopathological exam demonstrated sub-mucosal ossification and cartilage in the sample. Her follow-up has been uneventful for 3 years. Case 2 was a 37-year-old man presented with hoarseness, exertional dyspnea, and intermittent dry cough for about 3 years. Chest CT scans showed irregular nodules around the entire circumference of the trachea extending from sub-glottic region to lower trachea. FOB showed glottic stenosis and diffused sub-mucosal calcified nodules protruding from the antero-lateral portion of the trachea in the subglottic region. Over the following 12 months, his disease is stable. Conclusions: TO is a rare, benign disease with slow progression, clinicians should be aware of TO and should consider it in patients with chronic cough, recurrent respiratory infection and evolving exertional dyspnea.
机译：简介：气管支气管疾病osteochondroplastica（TO）是一种罕见的疾病，累及气管支气管树腔，其特征是气管和支气管中有多个粘膜下骨和软骨结节，并保留后壁。我们在此报告2例气管支气管病性骨软骨病患者，并简要回顾相关文献。病例介绍：病例1是一位64岁的女性，患有慢性阻塞性肺病（COPD），曾出现2年频繁的非生产性咳嗽。胸部计算机断层扫描（CT）显示出与COPD一致的征兆，以及由钙化灶引起的气管和两个主要支气管腔明显不规则变窄。进行了纤维支气管镜检查（FOB），发现数十个粘膜下结节伸入气管下半部腔和两个主支气管。组织病理学检查显示样本中粘膜下骨化和软骨。她的随访三年来一直平稳。案例2是一名37岁的男子，出现声音嘶哑，劳累性呼吸困难和间歇性干咳约3年。胸部CT扫描显示，气管从声门下区域一直延伸到下气管，整个气管周围均出现不规则结节。 FOB显示声门狭窄，并在声门下区域从气管前外侧部分伸出弥散的粘膜下钙化结节。在接下来的12个月中，他的病情稳定。结论：TO是一种罕见的良性疾病，进展缓慢，临床医生应注意TO，并应在患有慢性咳嗽，反复呼吸道感染和劳累性呼吸困难的患者中考虑使用TO。

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