Toxicokinetic models and their applications

机译：毒代动力学模型及其应用

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In this paper toxicokinetics was examined. Chemical distribution, absorption and elimination in the living organism were investigated. The aim of this paper kinetic of toxic substance during exposure in a biological system was studied. Several toxicokinetic models using physiological and biochemical parameters were derived. Physiologically based toxicokinetic models and similar pharmacokinetic models were represented. Physiological changes during chronic exposure to a xenobiotic are introduced. This paper contributes toxicokinetics investigation with the aim to pediction the contamined biological system behavior.

机译：本文研究了毒代动力学。研究了生物体内化学物质的分布，吸收和消除。本文旨在研究有毒物质在生物系统中的暴露动力学。利用生理和生化参数推导了几种毒代动力学模型。代表了基于生理学的毒物动力学模型和类似的药代动力学模型。介绍了长期暴露于异种生物过程中的生理变化。本文为毒理动力学研究做出贡献，旨在对受污染的生物系统行为进行矫正。

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《Recent researches in sociology, financing, environment and health sciences》|2011年|p.287-292|共6页
会议地点 Playa Meloneras(ES);Playa Meloneras(ES);Playa Meloneras(ES);Playa Meloneras(ES);Playa Meloneras(ES);Playa Meloneras(ES)
作者
L. Zivkovic;
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作者单位

Toxicological Centre, Podgorica, Montenegro;

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会议组织
原文格式 PDF
正文语种 eng
中图分类社会生活与社会问题;
关键词
chemicals; kinetics; toxic effect; chronic; living organism;

机译：化学药品动力学;毒性作用慢性生物体;

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1. Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats. [J] . van Asperen J, Rijcken WR, Lammers JH Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2003,第1a2期

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2. Modeling Exposure-Biomarker Relationships: Applications of Linear and Nonlinear Toxicokinetics [J] . Johnson BA, Kupper LL, Taylor DJ, Journal of Agricultural, Biological, and Environmental Statistics . 2005,第4期

机译：建模暴露-生物标志物的关系：线性和非线性毒物动力学的应用
3. Modeling exposure-biomarker relationships: Applications of linear and nonlinear toxicokinetics [J] . Brent A. Johnson, Lawrence L. Kupper, Douglas J. Taylor, Journal of Agricultural, Biological, and Environmental Statistics . 2005,第4期

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4. Toxicokinetic models and their applications [C] . L. Zivkovic WSEAS International Conference on Management, Marketing and Finances . 2011

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5. A physiologically based toxicokinetic (PBTK) model for inhalation exposure to benzene and its engineering applications. [D] . Kulkarni, Tara Aniket. 2004

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8. Probabilistic Methods for Addressing Uncertainty and Variability in Biological Models: Application to a Toxicokinetic Model [R] . Banks, H. T. , Potter, L. K. 2002

机译：解决生物模型中不确定性和变异性的概率方法：应用于毒代动力学模型

Toxicokinetic models and their applications

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