首页> 外文会议>Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications III >A Minimally Invasive Multifunctional Nanoscale System for Selective Targeting, Imaging, and NIR Photothermal Therapy of Malignant Tumors
【24h】

A Minimally Invasive Multifunctional Nanoscale System for Selective Targeting, Imaging, and NIR Photothermal Therapy of Malignant Tumors

机译:用于恶性肿瘤的选择性靶向,成像和NIR光热疗法的微创多功能纳米系统。

获取原文
获取原文并翻译 | 示例

摘要

The anti-EGFR antibody, cetuximab, was labeled with IRDye 800CW fluorescent dye and conjugated to gold nanorods (GNR). GNR with aspect ratio of ~ 4 and plasmon resonance peak at ~785 nm were fabricated for use in these experiments. The IRDyexetuximabrnanorod conjugate treatment with NIR light selectively heated the GNR and was sufficient to treat cancers. Excitation induced fluorescence of the IRDye 800CW enabling real-time imaging. We characterized and optimized the parameters for the conjugation of the GNR to cetuximab to facilitate active targeting of the nanorods to the site of the tumor. This combination of selective targeting, imaging, and photothermal treating of malignant cells is a viable approach for a variety of squamous cell carcinomas.
机译:抗EGFR抗体西妥昔单抗用IRDye 800CW荧光染料标记,并与金纳米棒(GNR)偶联。制备了宽高比为〜4的GNR和〜785 nm的等离子体共振峰。用NIR光对IRDyexetuximabrnanorod进行共轭治疗选择性地加热了GNR,足以治疗癌症。激发引起的IRDye 800CW荧光使实时成像成为可能。我们表征并优化了将GNR与西妥昔单抗结合的参数,以利于将纳米棒主动靶向至肿瘤部位。选择性靶向,成像和光热治疗恶性细胞的这种结合是多种鳞状细胞癌的可行方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号