• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Scientia pharmaceutica >Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach
【24h】

Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach

机译：洞察2-烷基-4-（联苯甲氧基）喹啉作为非肽血管紧张素II受体拮抗剂的结构要求：一种QSAR方法

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl-4-(biphenylylmethoxy)quinolines as angiotensin II (Ang II) receptor antagonists by using Chem 3D and Dragon Software. The studies, carried out on 33 analogs, give statistically significant correlations of selective Ang II antagonistic activity with physical properties concerning size, symmetry, shape and distribution of molecule atoms. Among several 2D quantitative structure activity relationship models, one model gave good statistical significance (r>0.81, F-test = 10.47, S < 0.30, chance correlation < 0.01). 3D QSAR studies show that Hennery's law constant, Dipole and VDWE play a significant role in Ang II antagonistic activity. These QSAR studies help us in the design and prediction of novel substituted benzimidazole Ang II receptor antagonists.
机译：在当前研究中，使用顺序多元线性回归分析的定量结构活性关系方法通过使用Chem 3D和Dragon软件应用于一系列作为血管紧张素II（Ang II）受体拮抗剂的2-烷基-4-（联苯基甲氧基）喹啉。对33种类似物进行的研究给出了选择性Ang II拮抗活性与有关分子原子的大小，对称性，形状和分布的物理性质的统计学显着相关性。在几个二维定量结构活性关系模型中，一个模型具有良好的统计学意义（r> 0.81，F检验= 10.47，S <0.30，机会相关性<0.01）。 3D QSAR研究表明，Hennery定律常数，偶极子和VDWE在Ang II拮抗活性中起重要作用。这些QSAR研究有助于我们设计和预测新型取代的苯并咪唑Ang II受体拮抗剂。

著录项

  • 来源
    《Scientia pharmaceutica》|2009年|33-45|共13页
  • 会议地点 Vienna(AT)
  • 作者

    Vivek K. Vyas; Anurekha Jain; Suresh C. Mahajan; Radheshyam Patidar; Sunil Mistry; Subhash C. Chaturvedi;

  • 作者单位

    Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India;

    B. R. Nahata College of Pharmacy, Department of Medicinal Chemistry, Rajiv Gandhi Technical University, Mhow-Neemuch Road 458001 Mandsaur (M.P.) India;

    Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India;

    Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India;

    Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India;

    School of Pharmacy Devi Ahilya Vishwavidylaya, Takshashila Parisar Khandwa road, 4520;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    QSAR; angiotensin II antagonists; hypertension; AT1 and AT2 receptor;

    机译：QSAR；血管紧张素II拮抗剂；高血压; AT1和AT2受体;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号