Biologically active surfaces using chemical vapor deposition polymerization

机译：使用化学气相沉积聚合的生物活性表面

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We have demonstrated the feasibility of using these reactive polymers to control non-specific protein adsorption on different substrates. More importantly, experiments have also been conducted with 3-D patterning in a PDMS-based microfluidic channel demonstrating the creation of spatially controlled non-fouling surfaces in 3-D geometries. In addition, the photopatterning method overcomes the continuous patterns in laminar flow patterning. This novel technique consists of two steps: (1) CVD polymerization of the photodefinable coating, and (2) photopatterning. This generic surface engineering protocol is widely applicable to a range of biomaterials and even hybrid devices, because of the substrate independence of the CVD coating step. With the precise control of non-specific protein adsorption and the ease of photopatterning technique in three dimensions, we foresee the technology to be useful for the design of novel biomaterials or for "BioMEMS" applications.

机译：我们已经证明了使用这些反应性聚合物控制非特异性蛋白质在不同基质上的吸附的可行性。更重要的是，还已经在基于PDMS的微流体通道中对3-D图案进行了实验，证明了在3-D几何形状中创建了空间可控的无污垢表面。另外，光图案化方法克服了层流图案化中的连续图案。该新技术包括两个步骤：（1）光定义涂层的CVD聚合，以及（2）光图案化。由于CVD涂层步骤的基材独立性，因此这种通用的表面工程规程可广泛应用于各种生物材料甚至混合设备。通过精确地控制非特异性蛋白质吸附和易于在三个维度上进行光图案化技术，我们预计该技术可用于设计新型生物材料或“ BioMEMS”应用。

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《Society for Biomaterials Transaction of the 31st Annual Meeting vol.XXIX pt.2》|2006年|P.660|共1页
会议地点 PittsburghPA(US)
作者
Joerg Lahann; Himabindu Nandivada; Hsien_yeh Chen; Yaseen Elkasabi;
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Chemical Engineering, Materials Science and Engineering, and Macromolecular Science and Engineering, the University of Michigan, Ann Arbor, MI;

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原文格式 PDF
正文语种 eng
中图分类生物材料学;
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4. Biologically active surfaces using chemical vapor deposition polymerization [C] . Joerg Lahann, Himabindu Nandivada, Hsien_yeh Chen, Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 . 2006

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Biologically active surfaces using chemical vapor deposition polymerization

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