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首页> 外文会议>Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 >Biosynthetic Hydrogels Promote 3-D Outgrowth and Dedifferentiation at the Edge of Articular Cartilage Explants in an in vitro Model
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Biosynthetic Hydrogels Promote 3-D Outgrowth and Dedifferentiation at the Edge of Articular Cartilage Explants in an in vitro Model

机译：在体外模型中，生物合成水凝胶促进关节软骨外植体边缘的3D生长和去分化。

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摘要

The distinct biochemical composition of articular cartilage is maintained by highly differentiated cartilage cells called chondrocytes. Chondrocytes have a limited capacity for repairing articular cartilage, and without a vascular supply and limited presence of undifferentiated cells, focal injuries to the joint surface ultimately result in progressive degeneration of the cartilage. This limitation has led to some speculation about the restricted motility of differentiated chondrocytes in their extracellular environment during wound healing. In the present investigation, we explore a cellular ingrowth matrix cartilage repair strategy using photo-polymerizable biodegradable hydrogels made from PEGylated protein polymers. The degradable hydrogels are used to encapsulate articular cartilage explants in order to assess the 3-D outgrowth and cell differentiation of chondrocytes after cartilage injury using an in vitro wound repair model. This model is further used to assess the influence of the chondrogenic growth factors IGF-1 and TGF-β on the phenotype of the motile chondrocytes after they enter into and proliferate within the hydrogel matrix.
机译：关节软骨的独特生化成分由称为软骨细胞的高度分化的软骨细胞维持。软骨细胞修复关节软骨的能力有限，并且在没有血管供应和有限的未分化细胞存在的情况下，对关节表面的局灶性损伤最终导致软骨的逐渐退化。这种局限性导致人们对伤口愈合过程中分化的软骨细胞在细胞外环境中运动受限的推测。在本研究中，我们探索了使用由聚乙二醇化的蛋白质聚合物制成的可光聚合的可生物降解水凝胶的细胞向内生长基质软骨修复策略。为了评估软骨损伤后软骨细胞的3-D向外生长和细胞分化，可降解水凝胶用于包裹关节软骨外植体，方法是使用体外伤口修复模型。该模型还用于评估软骨生成生长因子IGF-1和TGF-β对活动性软骨细胞进入水凝胶基质并在其中扩散后的表型的影响。

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