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首页> 外文会议>Solid-state sensor and actuator workshop : Technical digest >A LOW DISPERSION TURN FOR MINIATURIZED ELECTROPHORESIS
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A LOW DISPERSION TURN FOR MINIATURIZED ELECTROPHORESIS

机译：低分散度，可实现最小化的电泳

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摘要

Many chip-based microcolumn separation systems requirernserpentine channels to obtain longer separation lengths within arncompact area. However, analyte bands traveling through curvedrnchannels experience increased dispersion and thus, serpentinernchannels reduce the intended benefit of the increased channelrnlength. We have used simulation tools to predict this increasedrnband dispersion and then to design a comer geometry that causesrnless dispersion. Experiments using bleached- and cagedrnfluorescence visualization were conducted to verify the proposedrnturn designs. We demonstrate experimentally that the new comerrndesign greatly reduces dispersion of analyte bands. Quantitativernand qualitative comparisons can be made between the simulationsrnand experiments, and these results suggest that the simulations canrnbe used effectively as design tools.
机译：许多基于芯片的微柱分离系统需要蛇纹石通道才能在紧凑型区域内获得更长的分离长度。然而，穿过弯曲通道的分析物谱带经历了增加的分散，因此，蛇形内通道降低了增加通道长度的预期好处。我们已经使用仿真工具来预测这种增大的色带色散，然后设计导致无色散的拐角几何形状。进行了使用漂白和笼式荧光可视化的实验，以验证所提出的匝道设计。我们通过实验证明，新的comerrndesign大大减少了分析物谱带的分散。可以在仿真和实验之间进行定量和定性比较，这些结果表明仿真可以有效地用作设计工具。

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  • 来源
  • 会议地点 Hilton Head Island SC(US)
  • 作者

    Joshua I. Molho; Amy E. Herr; Bruce P. Mosier; Juan G. Santiago; Thomas W. Kenny; Reid A. Brennen; Gary B. Gordon;

  • 作者单位

    Mechanical Engineering Department, Stanford University Stanford, CA 94305-4021;

    Mechanical Engineering Department, Stanford University Stanford, CA 94305-4021;

    Mechanical Engineering Department, Stanford University Stanford, CA 94305-4021;

    Mechanical Engineering Department, Stanford University Stanford, CA 94305-4021;

    Mechanical Engineering Department, Stanford University Stanford, CA 94305-4021;

    Agilent Laboratories, Agilent Technologies Palo Alto, CA 94304-1392;

    Agilent Laboratories, Agilent Technologies Palo Alto, CA 94304-1392;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TM938.865;
  • 关键词

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