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首页> 外文会议>Space Technology amp; Applications International Forum (STAIF-99) ptol January 31-February 4, 1999, Albuquerque Hyatt Hotel, NM >Protein crystal growth in microgravity: status and commercial implications
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Protein crystal growth in microgravity: status and commercial implications

机译：微重力下的蛋白质晶体生长：现状和商业意义

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摘要

Since 1985, The Center for Macromolecular Crystallography has conducted an extensive program of macromolecular crystal growth epxeriments n microgravity. This Center has designed and built crystal growth flight hardwarre that has an excellent productivity and reliability record. In addition, several other crystallography laboratories have conducted macromolecular crystal growth experiments in microgravity and developed hardware to house their experiments. These experiments have successfully demonstrated that the low gravity environment can be used to produce crystals of proteins and other macromolecules that are superior to crystals of the same compounds grown on earth. Improved, extended x-ray diffraction data collected from space-grown crystals has contributed to the solution of the three-dimensional structures of many proteins and has augmented structure-based drug design studies targeting several diseases and degrenerative conditions. The production of produce high-quality crystals of medically relevent macromolecules is important because of the rapidly growing role of macromolecular crystallography in biology and medicine. Large, high-quality crystals arre critical to solving the structures of biologically important macromolecules, but it is often difficult to botain these crystals because of the physical and chemical properties of the compounds. Work by this and other crystallography laboratories has shown that conducting macromolecular crystallization expoeriments in the microgravity environment alleviates convection and sedimentation effects, and frequently results in crystals that yield x-ray diffraction data that is superior to their earth-grown counterparts. The improved diffraction data translates directly to faster, more accurate solutions to the three-dimensional structures of the target molecules.
机译：自1985年以来，大分子晶体学研究中心已开展了一项涵盖大分子晶体生长和微重力的广泛计划。该中心设计并建造了具有出色生产率和可靠性记录的晶体生长飞行硬体。此外，其他几个晶体学实验室已经在微重力下进行了大分子晶体生长实验，并开发了用于容纳其实验的硬件。这些实验已成功证明，低重力环境可用于生产蛋白质和其他大分子的晶体，该晶体优于地球上生长的相同化合物的晶体。从空间生长的晶体中收集到的经过改进的扩展X射线衍射数据有助于解决许多蛋白质的三维结构，并针对多种疾病和退化性疾病，开展了基于结构的药物设计研究。由于大分子晶体学在生物学和医学中的迅速增长的作用，生产高质量的医学相关大分子晶体非常重要。大型，高质量的晶体对于解决生物学上重要的大分子的结构至关重要，但是由于这些化合物的物理和化学性质，通常难以制成这些晶体。该实验室和其他晶体学实验室的工作表明，在微重力环境中进行大分子结晶实验可减轻对流和沉降作用，并经常导致晶体产生的X射线衍射数据优于其在地球上生长的晶体。改进的衍射数据直接转化为目标分子三维结构的更快，更准确的解决方案。

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