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Two-dimensional microcirculation mapping with real time spatial frequency domain imaging

机译:具有实时空间频域成像的二维微循环映射

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We present a spatial frequency domain imaging (SFDI) study of local hemodynamics in the human finger cuticle of healthy volunteers performing paced breathing and the forearm of healthy young adults performing normal breathing with our recently developed Real Time Single Snapshot Multiple Frequency Demodulation - Spatial Frequency Domain Imaging (SSMD-SFDI) system. A two-layer model was used to map the concentrations of deoxy-, oxy-hemoglobin, melanin, epidermal thickness and scattering properties at the subsurface of the forearm and the finger cuticle. The oscillations of the concentrations of deoxy- and oxy-hemoglobin at the subsurface of the finger cuticle and forearm induced by paced breathing and normal breathing, respectively, were found to be close to out-of-phase, attributed to the dominance of the blood flow modulation by paced breathing or heartbeat. Our results suggest that the real time SFDI platform may serve as one effective imaging modality for microcirculation monitoring.
机译:我们使用我们最近开发的实时单快照多频率解调-空间频率域,对进行定速呼吸的健康志愿者和健康年轻人的前臂进行正常呼吸的人类手指角质层中的局部血液动力学进行空间频域成像(SFDI)研究。成像(SSMD-SFDI)系统。使用两层模型绘制前臂和手指角质层下的脱氧,氧合血红蛋白,黑色素,表皮厚度和散射特性的浓度。节奏呼吸和正常呼吸分别导致手指角质层和前臂下表面的脱氧和氧合血红蛋白浓度波动接近于异相,这归因于血液的优势通过有节奏的呼吸或心跳来调节流量。我们的结果表明,实时SFDI平台可作为一种用于微循环监测的有效成像方式。

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