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首页> 外文期刊>Journal of biomedical optics >Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging
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Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging

机译：使用高光谱空间频域成像技术将药物递送至脑组织的空间图

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摘要

We present an application of spatial frequency-domain imaging (SFDI) to the wide-field imaging of drug delivery to brain tissue. Measurements were compared with values obtained by a previously validated variation of diffuse reflectance spectroscopy, the method of optical pharmacokinetics (OP). We demonstrate a cross-correlation between the two methods for absorption extraction and drug concentration determination in both experimental tissue phantoms and freshly extracted rodent brain tissue. These methods were first used to assess intra-arterial (IA) delivery of cationic liposomes to brain tissue in Sprague Dawley rats under transient cerebral hypoperfusion. Results were found to be in agreement with previously published experimental data and pharmacokinetic models of IA drug delivery. We then applied the same scheme to evaluate IA mitoxantrone delivery to glioma-bearing rats. Good correlation was seen between OP and SFDI determined concentrations taken from normal and tumor averaged sites. This study shows the feasibility of mapping drug/tracer distributions and encourages the use of SFDI for spatial imaging of tissues for drug/tracer-tagged carrier deposition and pharmacokinetic studies.
机译：我们提出了空间频域成像（SFDI）在药物输送到脑组织的广域成像中的应用。将测量结果与通过先前验证的漫反射光谱法（光学药代动力学（OP）方法）的变化获得的值进行比较。我们证明了在两种实验组织模型和新鲜提取的啮齿动物脑组织中用于吸收提取和药物浓度测定的两种方法之间的互相关性。这些方法首先用于评估在短暂脑灌注不足下Sprague Dawley大鼠脑组织中阳离子脂质体向动脉内的递送。发现结果与先前发表的IA药物递送的实验数据和药代动力学模型一致。然后，我们应用了相同的方案来评估IA米托蒽醌向荷胶质瘤大鼠的递送。从正常和肿瘤平均部位获得的OP和SFDI测定浓度之间发现良好的相关性。这项研究显示了绘制药物/示踪剂分布图的可行性，并鼓励将SFDI用于组织空间成像以进行药物/示踪剂标记的载体沉积和药代动力学研究。

著录项

  • 来源
    《Journal of biomedical optics》 |2014年第9期|096003.1-096003.9|共9页
  • 作者

    Rajinder P. Singh-Moon; Darren M. Roblyer; Irving J. Bigio; Shailendra Joshi;

  • 作者单位

    Columbia University College of Physicians and Surgeons, Department of Anesthesiology, 630 West 168th Street, New York, New York 10032, United States;

    Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215, United States;

    Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215, United States,Boston University, Department of Electrical Engineering, 44 Cummington Street, Boston, Massachusetts 02215, United States;

    Columbia University College of Physicians and Surgeons, Department of Anesthesiology, 630 West 168th Street, New York, New York 10032, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hyperspectral imaging; diffuse reflectance; spectroscopy; spatial frequency domain; drug delivery; mitoxantrone;

    机译：高光谱成像漫反射率光谱学空间频域药物输送;米托蒽醌;

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