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首页> 外文会议>High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management >Evaluation of a high framerate multi-exposure laser speckle contrast imaging setup
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Evaluation of a high framerate multi-exposure laser speckle contrast imaging setup

机译：评估高帧率多曝光激光散斑对比度成像设置

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摘要

We present a first evaluation of a new multi-exposure laser speckle contrast imaging (MELSCI) system for assessing spatial variations in the microcirculatory perfusion. The MELSCI system is based on a 1000 frames per second 1-megapixel camera connected to a field programmable gate arrays (FPGA) capable of producing MELSCI data in realtime. The imaging system is evaluated against a single point laser Doppler flowmetry (LDF) system during occlusion-release provocations of the arm in five subjects.Perfusion is calculated from MELSCI data using current state-of-the-art inverse models. The analysis displayed a good agreement between measured and modeled data, with an average error below 6%. This strongly indicates that the applied model is capable of accurately describing the MELSCI data and that the acquired data is of high quality. Comparing readings from the occlusion-release provocation showed that the MELSCI perfusion was significantly correlated (R=0.83) to the single point LDF perfusion, clearly outperforming perfusion estimations based on a single exposure time.We conclude that the MELSCI system provides blood flow images of enhanced quality, taking us one step closer to a system that accurately can monitor dynamic changes in skin perfusion over a large area in real-time.
机译：我们提出了一种新的多曝光激光散斑对比度成像（MELSCI）系统的首次评估，以评估微循环灌注中的空间变化。 MELSCI系统基于连接到现场可编程门阵列（FPGA）的每秒1000帧的1百万像素摄像机，能够实时产生MELSCI数据。在五个对象的手臂阻塞释放过程中，使用单点激光多普勒血流仪（LDF）系统对成像系统进行了评估，并使用当前最新的逆模型从MELSCI数据计算出灌注。分析显示测量数据和建模数据之间的一致性很好，平均误差低于6％。这有力地表明，所应用的模型能够准确地描述MELSCI数据，并且所获取的数据具有高质量。比较闭塞释放激发的读数显示，MELSCI灌注与单点LDF灌注显着相关（R = 0.83），明显优于基于单次暴露时间的灌注估计。我们得出的结论是MELSCI系统提供的血流图像更高的质量，使我们更接近于可以实时监控大面积皮肤灌注动态变化的系统，这一步又近了一步。

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