Radiation can induce a chemical reaction to modify polymer under even soild conditions or in low temperatures. Radiation crosslinking can be easily adjusted and is easily reproducible by controlling the radiation dose. The finished product contains no residues of substances required in initiate the chemical crosslinking which can restrict the application possibilities. In these studies, hydrogels from a mixture of chitosan and polyvinyl alcohol(PVA)/Poly-N-Ninylpyrrolidone(PVP) were made by "freezing and thawing", or gamma-ray irradiation or two steps of "freezing and thawing" and gamma-ray irradiation for wound dressing.
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