ASSEMBLY OF PHARMACEUTICAL MICROPARTICLES VIA SPRAY DRYING

机译：喷雾干燥法制备的药物微颗粒

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Pharmaceutical microparticles require stringent control over their characteristics to realize their optimal therapeutic performance.Spray drying represents an elegant onestep route for the production of pharmaceutical microparticles,although a typical feature of conventional spray-dried products is the significant variation in particle properties.Hereby,the synthesis of pharmaceutical microparticles with homogeneous characteristics is possible with a micro-fluidic jet spray drying technique.This progress facilitates the methodical study on the direct relationship among formulation,production,physicochemical properties,and functionalities of these pharmaceutical microparticles via the spray-drying route.Several examples on the design and assembly of microparticles with tailor-made properties and functionalities are presented,with specific emphasis on the control over particle size,shape,microstructures,and controlled release kinetics.The underlying particle formation mechanisms and design concepts presented here are not limited to pharmaceutical components but to other functional particles as well.

机译：药物微粒需要严格控制其特性以实现最佳治疗性能。喷雾干燥代表了制备药物微粒的一条优雅的一步之路，尽管常规喷雾干燥产品的典型特征是颗粒性质的显着变化。通过微流控喷射干燥技术可以合成具有均一特性的药物微粒。这一进展促进了通过喷雾干燥途径对这些药物微粒的配方，生产，理化性质和功能性之间的直接关系进行系统的研究。给出了几个具有定制性能和功能的微粒设计和组装的例子，其中重点是对粒径，形状，微结构和控释动力学的控制。潜在的颗粒形成机理和设计此处介绍的gn概念不仅限于药物成分，还包括其他功能性颗粒。

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来源
《The 18th international drying symposium》|2012年|1-7|共7页
会议地点 Xiamen(CN)
作者
W.Liu; C.Selomulya; X.D.Chen;
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作者单位

Department of Chemical Engineering,Monash University,VIC,3800,Australia;

Department of Chemical Engineering,Monash University,VIC,3800,Australia;

Department of Chemical and Biochemical Engineering,College of Chemistry and Chemical Engineering,Xiamen University Fujian Province,361005,P.R.China;

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会议组织
原文格式 PDF
正文语种 eng
中图分类空气处理;
关键词
pharmaceutical particles; micro-fluidic jet spray drying; microstructure; controlled release;

机译：药物颗粒；微流喷射干燥；微观结构；控释;

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机译：粘性药物喷雾干燥的工艺开发;生物粘附尼古丁微粒用于压缩药物口香糖的案例研究。
4. ASSEMBLY OF PHARMACEUTICAL MICROPARTICLES VIA SPRAY DRYING [C] . W.Liu, C.Selomulya, X.D.Chen International drying symposium . 2012

机译：通过喷雾干燥组装药物微粒
5. A study of the physical and chemical stability of spray dried aluminum hydroxycarbonate and of drying methods for aluminum hydroxycarbonate gel: Part I. The physical and chemical stability of spray dried aluminum hydroxycarbonate gel. Part II. Drying methods for aluminum hydroxycarbonate gel. [D] . Hancock, Kim Elaine. 1994

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ASSEMBLY OF PHARMACEUTICAL MICROPARTICLES VIA SPRAY DRYING

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