• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Optical Tomography and Spectroscopy of Tissue XIII >Hand-held multi-wavelength spatial frequency domain imaging for breast cancer imaging
【24h】

Hand-held multi-wavelength spatial frequency domain imaging for breast cancer imaging

机译：用于乳腺癌成像的手持式多波长空间频域成像

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During neoadjuvant chemotherapy for breast cancer, little information is available on the response or non-response of thetumor to the treatment. Pathologic complete response is correlated with survival, but patients and clinicians both must waituntil after the patient undergoes surgery and the resected tissue is analyzed in order to assign pathologic response. Becausestructural imaging modalities and clinical palpation are poor predictors of pathologic response, there is need for aninexpensive imaging method which is sensitive to the changing physiology of the tumor. Such a method should be noninvasive,to permit frequent monitoring during therapy. Near-infrared optical imaging has already shown promise formonitoring neoadjuvant chemotherapy, with measurement of hemodynamics providing additional information overbaseline chromophore concentrations. These contrasts rely on the highly vascularized nature of most breast tumors, as wellas the abnormal vasculature, which can produce a different response to perturbations than healthy tissue. Here we describethe development of a new held-held spatial-frequency domain imaging (SFDI) device, to be used for measuring theresponse of breast tissue to local compression. Device design is described, as well as validation on optical phantoms, andin vivo. Compression studies were performed in soft optical phantoms containing stiff, tumor-mimicking inclusions, whichindicate the potential for compression to be used to bring stiff lesions within a depth which can be measured with SFDI.Additionally, the hemodynamic response of pressure cuff venous occlusion is described, measured on the forearm, andthis response is contrasted with the hemodynamic response to local tissue compression.
机译：在乳腺癌的新辅助化疗期间，几乎没有关于肿瘤对治疗的反应或无反应的信息。病理完全缓解与生存相关，但是患者和临床医生都必须在患者接受手术并分析切除的组织后等待，直到分配病理缓解。由于结构成像方式和临床触诊不能很好地预测病理反应，因此需要一种对肿瘤生理变化敏感的廉价成像方法。这种方法应该是非侵入性的，以允许在治疗期间进行频繁监测。近红外光学成像已显示出监测新辅助化疗的希望，其血流动力学测量可提供超过基线发色团浓度的更多信息。这些对比依赖于大多数乳腺肿瘤的高度血管化性质，以及异常脉管系统，与健康组织相比，异常脉管系统可对扰动产生不同的反应。在这里，我们描述了一种新的手持式空间频域成像（SFDI）设备的开发，该设备将用于测量乳腺组织对局部压迫的响应。描述了设备设计以及光学体模和体内验证。压缩研究是在包含僵硬，模仿肿瘤的包裹体的软光学模型中进行的，\ r \ n表明压缩的潜力可将僵硬的病变带入可以用SFDI测量的深度。\ r \ n此外，血液动力学响应描述了在前臂上测量的压力袖带静脉阻塞的变化，并且该响应与对局部组织受压的血液动力学响应形成对比。

著录项

  • 来源
    《Optical Tomography and Spectroscopy of Tissue XIII》|2019年|108740U.1-108740U.7|共7页
  • 会议地点 1605-7422;2410-9045
  • 作者

    Constance M. Robbins; Jason Yang; James F. Antaki; Jana M. Kainerstorfer;

  • 作者单位

    Dept. of Biomedical Engineering, Carnegie Mellon Univ., 5000 Forbes Ave, Pittsburgh, PA 15213;

    Dept. of Biomedical Engineering, Carnegie Mellon Univ., 5000 Forbes Ave, Pittsburgh, PA 15213;

    Dept. of Biomedical Engineering, Cornell Univ., 237 Tower Rd., Ithaca, NY 14850 jkainers@andrew.cmu.edu phone 1 412 268 5781 fax 1 412 268 1173;

    Dept. of Biomedical Engineering, Carnegie Mellon Univ., 5000 Forbes Ave, Pittsburgh, PA 15213;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号