DEVELOPMENT OF MICROFLUIDIC SHEAR ASSAYS FOR QUANTITATIVE ANALYSIS OF CELL ADHESION

机译：用于细胞粘附定量分析的微流体剪切测定法的发展

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We report a series of microfluidic shear devices for studying cell adhesion on biological substrates. The method provides a tool for performing high throughput experiments with small amounts of sample and number of cells. Furthermore, it allows access to regimes of large adhesion strength that are difficult for conventional cell adhesion assays. We also demonstrate long-term cell culturing and experiments with medium perfusion in such microfluidic devices. These microfluidic devices could provide useful insight for tissue engineering and cell mechanotransduction studies.

机译：我们报告了一系列的微流体剪切装置，用于研究生物基质上的细胞粘附。该方法提供了用于以少量样品和少量细胞进行高通量实验的工具。此外，它允许使用常规细胞粘附测定难以达到的大粘附强度的方案。我们还演示了在此类微流体设备中进行长期细胞培养和培养基灌注实验。这些微流体装置可以为组织工程和细胞机械转导研究提供有用的见识。

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来源
《μTAS 2002 Symposium on Micro Total Analysis Systems 2002 Vol.2 Nov 3-7, 2002 Nara, Japan》|2002年|p.784-786|共3页
会议地点 Nara(JP);Nara(JP)
作者
Hang Lu; Lily Y. Koo; Linda Griffith; Klavs F. Jensen;
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作者单位

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. 66-560, Cambridge, MA 02139, USA;

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会议组织
原文格式 PDF
正文语种 eng
中图分类 Q8;
关键词
cell adhesion; shear; high throughput;

机译：细胞粘附;剪切;高通量;
入库时间 2022-08-26 14:10:05

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专利

1. Microfluidic shear devices for quantitative analysis of cell adhesion [J] . Lu H, Koo LY, Wang WCM, Analytical chemistry . 2004,第18期

机译：微流体剪切装置用于细胞粘附的定量分析
2. Quantification of the adhesion strength of fibroblast cells on ethylene glycol terminated self-assembled monolayers by a microfluidic shear force assay [J] . Christof Christophis, Michael Grunze, Axel Rosenhahn Physical chemistry chemical physics: PCCP . 2010,第17期

机译：通过微流体剪切力测定法测量乙二醇封端的自组装单层的成纤维细胞粘合强度
3. Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay. [J] . B Angres, A Barth, W J Nelson Journal of cell biology . 1996,第2期

机译：从初始到稳定的细胞粘附转变的机制：使用定量粘附测定法对E-钙粘蛋白介导的粘附进行动力学分析。
4. DEVELOPMENT OF MICROFLUIDIC SHEAR ASSAYS FOR QUANTITATIVE ANALYSIS OF CELL ADHESION [C] . Hang Lu, Lily Y. Koo, Linda Griffith, International conference on miniaturized chemical and biochemical analysis systems . 2002

机译：微流体剪切测定的发展，用于定量分析细胞粘附性
5. Molecular recognition for the development of microfluidic toxin sensors and adhesion assays. [D] . Frisk, Megan Louise. 2009

机译：用于开发微流毒素传感器和粘附测定的分子识别。
6. Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay [O] . 1996

机译：从初始到稳定的细胞粘附转变的机制：使用定量粘附测定法对E-钙粘蛋白介导的粘附进行动力学分析
7. Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay [O] . 1996

机译：从初始到稳定的细胞粘附转变的机制：使用定量粘附测定法对E-钙粘蛋白介导的粘附进行动力学分析

DEVELOPMENT OF MICROFLUIDIC SHEAR ASSAYS FOR QUANTITATIVE ANALYSIS OF CELL ADHESION

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