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EPIDEMIOLOGICAL STUDY ON THE RELATION BETWEEN BREAST CANCER RISK AND ENDOGENOUS HORMONAL STATUS OF WOMEN IN TRANSYLVANIA COUNTY

机译：特兰西瓦尼亚县女性乳腺癌风险与内源性激素状况关系的流行病学研究

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Higher levels of endogenous hormones have long been hypothesized to increase the breast cancer risk. In a case-control study we assessed the reproductive factors linked to breast cancer risk (age at menarche, age at menopause, breast feeding, number of full-term pregnancies, age at first full-term pregnancy) using a validated questionnaire applied by interview to 223 breast cancer women and 211 controls. We calculated odds ratio to establish the relation between breast cancer risk and hormonal factors. The trend analyses shows the increasing or decreasing risk depending on the studied reproductive factors. The data were analyzed in Microsoft Excel 2000 and Epiinfo version 3.3.2. The results were considered significant statistically in wich p<0.05. The results of the study shows that early age at menarche and late menopause was a risk for breast cancer females, whereas breastfeeding and higher parity protect against breast cancer. This results are important for hormonedependent cases of breast cancer that can be prevented by modifiable lifestyle and environmental factors.

机译：长期以来一直假设较高水平的内源激素会增加患乳腺癌的风险。在一项病例对照研究中，我们使用经访谈验证的问卷，评估了与乳腺癌风险相关的生殖因素（初潮年龄，更年期年龄，母乳喂养，足月妊娠数，第一次足月妊娠的年龄）。 223名乳腺癌妇女和211名对照。我们计算了优势比，以建立乳腺癌风险与激素因素之间的关系。趋势分析表明，取决于研究的生殖因素，风险增加或降低。在Microsoft Excel 2000和Epiinfo版本3.3.2中分析了数据。结果被认为具有统计学显着性，至p ＜0.05。研究结果表明，初潮初潮和更年期晚期是乳腺癌女性的风险，而母乳喂养和更高的胎次可预防乳腺癌。该结果对于可通过改变生活方式和环境因素预防的激素依赖性乳腺癌病例很重要。

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《WSEAS international conference on medical physiology;WSEAS international conference on medical histology and embryology;WSEAS international conference on biochemistry and medical chemistry;WSEAS international conference on oncology;WSEAS international conference on medical pharmacology;WSEAS international conference on pathology;WSEAS international conference on psychiatry and psychotherapy;WSEAS international conference on cardiology;WSEAS international conference on surgery;WSEAS international conference on neurology;WSEAS international conference on gastroenterology;WSEAS international conference on ophthalmology;WSEAS international conference on obstetrics and gynaecology;WSEAS international conference on endocrinology》|2012年|145-149|共5页
会议地点 Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR);Kos Island(GR)
作者
BOGDANA NASUI; NINA CIUCIUC; DELIA HERGHEA; MONICA POPA;
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Department of Communitary Medicine Hygiene Discipline University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca;

Department of Epidemiology Oncologic Institute Ion Chiricuta Cluj-Napoca Cluj -Napoca Nasaud Street Nr. 6/3 Code 400610 ROMANIA;

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cancer risk; age at menarche; age at menopause; parity; breastfeeding.;

机译：癌症风险；初潮年龄绝经年龄平价;哺乳。;

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专利

1. Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case-control study. [J] . Masaaki Kawai, Yoichiro Kakugawa, Yoshikazu Nishino, Cancer causes and control: CCC . 2013,第5期

机译：与女性荷尔蒙受体和更年期状况相关的人体测量因素，体育活动和乳腺癌风险：一项病例对照研究。
2. Breast cancer and hormone replacement therapy (HRT): collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer [J] . V Beral, for the Collaborative Group on Hormonal Factors in Breast Cancer Breast Cancer Research . 2002,第Suppla1期

机译：乳腺癌和激素替代疗法（HRT）：对51,520例乳腺癌女性和108,411例非乳腺癌女性进行的51项流行病学研究数据的协作再分析
3. Reproductive factors and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women [J] . KawaiM., KakugawaY., NishinoY., Cancer science. . 2012,第10期

机译：与日本女性激素受体和更年期状况相关的生殖因子和乳腺癌风险
4. EPIDEMIOLOGICAL STUDY ON THE RELATION BETWEEN BREAST CANCER RISK AND ENDOGENOUS HORMONAL STATUS OF WOMEN IN TRANSYLVANIA COUNTY [C] . BOGDANA NASUI, NINA CIUCIUC, DELIA HERGHEA, WSEAS International Conference on Medical Physiology . 2012

机译：乳腺癌县乳腺癌风险与内源性荷尔蒙特地位的流行病学研究
5. Molecular stress signaling in breast epithelial cells: Characterization of the regulation of the breast cancer susceptibility gene 1 (BCRA1) by stress signaling, and, Design of an epidemiological study examining the effect of glucocorticoid receptor genetic variants on breast cancer risk [D] . Antonova, Lilia 2008

机译：乳腺上皮细胞中的分子应激信号传递：通过应激信号传递来表征乳腺癌易感基因1（BCRA1）的调节，以及一项流行病学研究的设计，旨在研究糖皮质激素受体基因变异对乳腺癌风险的影响
6. Breast cancer and hormone replacement therapy (HRT): collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer [O] . V Beral 2002

机译：乳腺癌和荷尔蒙替代疗法（HRT）：对51520例乳腺癌女性和108411例非乳腺癌女性进行的51项流行病学研究数据的协作再分析
7. Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Collaborative Group on Hormonal Factors in Breast Cancer [O] . van den Brandt, P.A., Goldbohm, R.A., et, al. 2002

机译：酒精，烟草和乳腺癌-对53项流行病学研究的单个数据进行的合作性重新分析，包括58,515名患有乳腺癌的妇女和95,067名没有该疾病的妇女乳腺癌荷尔蒙因素协作组
8. Epidemiologic Study of Genetic Variation in Hormonal Pathways in Relation to the Effect of Hormone Replacement Therapy on Breast Cancer Risk [R] . Reding, K. W. 2008

机译：激素替代疗法对乳腺癌风险影响的激素途径遗传变异的流行病学研究

EPIDEMIOLOGICAL STUDY ON THE RELATION BETWEEN BREAST CANCER RISK AND ENDOGENOUS HORMONAL STATUS OF WOMEN IN TRANSYLVANIA COUNTY

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