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Synthesis and characterization of interfaces between naturally derived and synthetic nanostructures for biomedical applications.

机译：用于生物医学应用的天然和合成纳米结构之间界面的合成和表征。

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摘要

The use of nanotechnology to develop methods for fabrication and characterization of organized hybrid nanostructures that include integrated polymeric, biological and inorganic compounds has increased exponentially during the last decade. Such bio-nanocomposite materials could be used in solving current biomedical problems spanning from nanomedicine to tissue engineering and biosensing.;In this dissertation, a systematic study has been carried out on the synthesis, characterization, of two interfaces between naturally derived and synthetic nanostructures. Carbon nanotubes and porous silicon represent the synthetic nanostructures that were developed for the purpose of interfacing with the naturally derived bovine type I collagen and respiratory syncytial virus DNA respectively. Firstly, the synthesis of collagen-carbon nanotubes by two different techniques: fibrillogenesis through slow wet fiber drawing (gelation process) and electrospinning has been highlighted. Characterization of the novel nanocomposite was conducted using electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, nanoindentation, and Raman spectroscopy. The collagen-carbon nanotube gelation process was found to have superior nanoscale surface mechanical properties that were more conducive to higher osteoblast specific protein expression such as osteocalcin. Applications of the developed nanofibers are detailed in the fields of orthopaedics and tissue engineering. Secondly, an overview of porous silicon synthesized by hydrofluoric acid is presented. A parametric study was performed to determine the optimal pore size was carried out. The use of porous silicon as a biosensor to detect RSV virus by DNA hybridization was then provided and the importance of the interface chemistry was highlighted.
机译：在过去的十年中，使用纳米技术来开发用于制造和表征包括集成的聚合物，生物和无机化合物的有组织杂化纳米结构的方法的数量呈指数增长。这种生物纳米复合材料可用于解决当前从纳米医学到组织工程和生物传感的生物医学问题。本文对天然和合成纳米结构之间的两种界面的合成，表征进行了系统的研究。碳纳米管和多孔硅代表了合成的纳米结构，这些纳米结构是为了分别与天然来源的牛I型胶原蛋白和呼吸道合胞病毒DNA接口而开发的。首先，突出了通过两种不同的技术合成胶原-碳纳米管：通过缓慢的湿法纤维拉伸（胶凝过程）和电纺丝产生纤维。使用电子显微镜，透射电子显微镜，傅立叶变换红外光谱，纳米压痕和拉曼光谱对新型纳米复合材料进行表征。发现胶原-碳纳米管胶凝过程具有优异的纳米级表面机械性能，其更有利于更高的成骨细胞特异性蛋白表达，例如骨钙蛋白。所开发的纳米纤维的应用在骨科和组织工程领域进行了详细介绍。其次，概述了由氢氟酸合成的多孔硅。进行参数研究以确定最佳孔径。然后提供了使用多孔硅作为通过DNA杂交检测RSV病毒的生物传感器，并强调了界面化学的重要性。

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  • 作者

    Zekri, Souheil.;

  • 作者单位

    University of South Florida.;

  • 授予单位 University of South Florida.;
  • 学科 Engineering Biomedical.;Engineering Mechanical.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 155 p.
  • 总页数 155
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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