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Electroconductive hydrogels: synthesis, characterization and biomedical applications.

机译:导电水凝胶:合成,表征和生物医学应用。

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摘要

Electroconductive hydrogels (ECHs) are composite biomaterials that bring together the redox switching and electrical properties of inherently conductive electroactive polymers (CEPs) with the facile small molecule transport, high hydration levels and biocompatibility of cross-linked hydrogels. General methods for the synthesis of electroconductive hydrogels as polymer blends and as polymer co-networks via chemical oxidative, electrochemical and/or a combination of chemical oxidation followed by electrochemical polymerization techniques are reviewed. Specific examples are introduced to illustrate the preparation of electroconductive hydrogels that were synthesized from poly(HEMA)-based hydrogels with polyaniline and from poly(HEMA)-based hydrogels with polypyrrole. The key applications of electroconductive hydrogels; as biorecognition membranes for implantable biosensors, as electro-stimulated drug release devices for programmed delivery, and as the low interfacial impedance layers on neuronal prostheses are highlighted. These applications provide great new horizons for these stimuli responsive, biomimetic polymeric materials.
机译:导电水凝胶(ECH)是复合生物材料,将固有导电性电活性聚合物(CEP)的氧化还原转换和电性能与便捷的小分子传输,高水合水平和交联水凝胶的生物相容性结合在一起。综述了通过化学氧化,电化学和/或化学氧化结合后通过电化学聚合技术合成导电水凝胶作为聚合物共混物和聚合物共网络的一般方法。引入具体实施例以说明导电性水凝胶的制备,该导电性水凝胶由具有聚苯胺的基于聚(HEMA)的水凝胶和具有聚吡咯的基于聚(HEMA)的水凝胶合成。导电水凝胶的关键应用;作为植入式生物传感器的生物识别膜,作为用于程序化递送的电刺激药物释放装置,以及在神经元假体上的低界面阻抗层,都得到了强调。这些应用为这些刺激响应性仿生聚合物材料开辟了广阔的前景。

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  • 来源
    《Biomaterials》 |2010年第10期|共16页
  • 作者

    Guiseppi Elie A;

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  • 正文语种 eng
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