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首页> 外文学位 >Effect of diet and sex on changes in gene expression and behavioral responses to chronic stress.
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Effect of diet and sex on changes in gene expression and behavioral responses to chronic stress.

机译：饮食和性别对基因表达变化和对慢性应激行为反应的影响。

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摘要

This work investigated the interaction between sex, stress, and dietary choice in rats. A preferred diet under the influence of chronic mild stress (CMS) was empirically determined to consist of soybeans and cookies mixed with lab chow. This mixed preferred diet was tested for its ability to mitigate the behavioral effects of CMS. Changes in the expression of genes selected for their known involvement in neurotrophic processes, response to stress, and appetite regulation were also studied in relation to these three factors.; Stressed rats of both sexes decreased their frequency of rearing and increased their attention to novelty. In the elevated plus maze, unstressed males but not females spent more time in the closed arm, even if fed the preferred diet. By stressing the animals, the "comforting" consequences of the preferred diet appeared to be overshadowed. In the forced swim test, females but not males fed the preferred diet showed increased immobility, whether stressed or not. Finally, females but not males showed a differential effect of diet under stress on the sucrose preference test. Only for the stressed females was the preferred diet effective in promoting sucrose intake, suggesting that the preferred diet did serve as a comfort food in this case. These results suggest that male and female rats differ in their susceptibility to the behavioral-modifying influences of CMS. And, to the extent that diet serves as a coping mechanism, it does so differently in males and females.; Differential results were reported in gene data that may well be explained by differences in the nature and duration of the chronic stress employed. In many cases, the gene expression changes found in our study showed regional differences between the hypothalamus and amygdala in their sensitivity to stress and diet. This suggests that different stressors activate different areas of the brain, and that distinct afferent pathways mediate responses specific to the nature of the stress. The most important conclusion of this study is that gene expression responses to stress depend on sex, diet, and brain region, in a pattern unique for each gene.
机译：这项工作调查了性别，压力和饮食选择之间的相互作用。根据经验确定，在慢性轻度压力​​（CMS）影响下的首选饮食包括大豆和饼干以及实验室食物。测试了这种混合的首选饮食缓解CMS行为影响的能力。还针对这三个因素研究了已知参与神经营养过程，对压力的反应和食欲调节的基因的表达变化。男女压力大的大鼠减少了饲养频率并增加了对新颖性的关注。在高架迷宫中，没有压力的雄性而不是雌性在密闭的手臂上花费更多的时间，即使进食了偏好的饮食也是如此。通过给动物施加压力，优选饮食的“舒适”后果似乎被掩盖了。在强迫游泳试验中，无论是否有压力，饲喂偏爱饮食的雌性而不是雄性显示出增加的不动。最后，雌性而不是雄性在蔗糖偏好测试中显示出在压力下饮食的差异作用。仅对于压力较大的女性而言，首选饮食有效地促进了蔗糖的摄入，这表明在这种情况下，首选饮食确实可以作为一种舒适食品。这些结果表明，雄性和雌性大鼠对CMS的行为改变影响的敏感性不同。而且，就饮食作为一种应对机制而言，它在男性和女性中的作用有所不同。在基因数据中报告了不同的结果，这可以很好地解释为所采用的慢性应激的性质和持续时间的差异。在许多情况下，我们研究中发现的基因表达变化表明，下丘脑和杏仁核对压力和饮食的敏感性存在区域差异。这表明不同的压力源会激活大脑的不同区域，并且不同的传入途径会介导针对压力性质的特定反应。这项研究最重要的结论是，基因表达对压力的反应取决于性别，饮食和大脑区域，这是每个基因独特的模式。

著录项

  • 作者

    Liang, Shuwen.;

  • 作者单位

    The University of Texas at El Paso.$bBiological Sciences.;

  • 授予单位 The University of Texas at El Paso.$bBiological Sciences.;
  • 学科 Biology Neuroscience.; Biology Animal Physiology.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 127 p.
  • 总页数 127
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;生理学;
  • 关键词

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