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首页> 外文会议>International Symposium on Hormonal Carcinogenesis >Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment
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Sex Hormone-binding Globulin Influences Gene Expression of LNCaP and MCF-7 Cells in Response to Androgen and Estrogen Treatment

机译：性激素结合球蛋白影响LNCAP和MCF-7细胞的基因表达响应雄激素和雌激素治疗

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Sex hormone-binding globulin (SHBG), a plasma protein that binds androgens and estrogens, also participates in the initial steps of a membrane-based steroid signaling pathway in human prostate and breast. We have recently shown that SHBG is expressed at the mRNA and protein levels in the prostate and breast. In this study, we addressed whether locally expressed SHBG: (1) Functions to regulate activation of membrane-based steroid signaling and (2) influences activation of the androgen (AR) and estrogen (ER) receptors. Using microarray analysis, we identified specific genes that are influenced by SHBG expression in LNCaP and MCF-7 cells in a manner consistent with each of these properties. These findings suggest that locally expressed SHBG can play a functional role in the steroid responsiveness of prostate and breast cells through multiple signaling pathways and that perturbations in local SHBG expression could contribute to prostate and breast cancer.
机译：性激素结合球蛋白（SHBG），其结合雌激素和雌激素的血浆蛋白，还参与人类前列腺和乳房中基于膜的类固醇信号通路的初始步骤。我们最近显示SHBG在前列腺和乳房的mRNA和蛋白质水平上表达。在该研究中，我们解决了局部表达的SHBG：（1）用于调节膜基类固醇信号传导的激活和（2）影响雄激素（AR）和雌激素（ER）受体的活化。使用微阵列分析，我们确定了通过与这些性质一致的方式受LNCAP和MCF-7细胞中的SHBG表达影响的特定基因。这些发现表明，局部表达的SHBG可以通过多信号传导途径在前列腺和乳腺细胞的类固醇反应性中起作用的功能作用，并且局部SHBG表达的扰动可能有助于前列腺和乳腺癌。

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