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Establishing Caenorhabditis elegans as a model for neural tube defects.

机译：建立秀丽隐杆线虫作为神经管缺陷的模型。

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NTDs such as spina bifida present a significant public health problem. The broad goal of this thesis was to establish the efficacy of C. elegans as a model for neural tube defects, allowing the molecular mechanisms of cell migrations associated with neural tube closure to be examined in a simple system. Alternative food sources, genetic components, and environmental variables (ethanol and valproic acid) were investigated. Folate pathway mutants had increased embryonic lethality, as did embryos from hermaphrodites grown in the presence of valproic acid and ethanol, but the effect level was variable. The variable outcomes may be a result of the multi- factorial nature of neural tube defects and the involved covariates. Based on these experiments, the most promising candidate approaches for examining the usefulness of C. elegans as a model for NTDs are genetic components in the folate pathway and in utero ethanol exposure.

机译：脊柱裂等非传染性疾病存在严重的公共卫生问题。本文的主要目标是建立秀丽隐杆线虫作为神经管缺陷模型的功效，从而允许在一个简单的系统中检查与神经管闭合相关的细胞迁移的分子机制。研究了其他食物来源，遗传成分和环境变量（乙醇和丙戊酸）。叶酸途径突变体具有增加的胚胎致死率，如在丙戊酸和乙醇存在下生长的雌雄同体胚胎，其影响程度却是可变的。结果的可变可能是神经管缺损及其相关协变量的多因素性质的结果。基于这些实验，用于检查秀丽隐杆线虫作为NTD模型的有用性的最有前途的候选方法是叶酸途径和子宫内乙醇暴露的遗传成分。

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作者
King, Chelle.;
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作者单位

Truman State University.;

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授予单位 Truman State University.;
学科 Biology Molecular.
学位 M.S.
年度 2010
页码 67 p.
总页数 67
原文格式 PDF
正文语种 eng
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机译：建立秀丽隐杆线虫作为鸟分枝杆菌亚种人肠杆菌感染和肠道定殖的模型建立秀丽隐杆线虫作为鸟分枝杆菌亚种人肠杆菌感染和肠道定殖的模型建立秀丽线虫
2. Molecular genetic analysis of human homologs of Caenorhabditis elegans mab-21-like 1 gene in patients with neural tube defects. [J] . Merello E, De Marco P, Moroni A, Birth defects research, Part A. Clinical and molecular teratology . 2004,第11期

机译：神经管畸形患者秀丽隐杆线虫mab-21-like 1基因人类同源物的分子遗传学分析。
3. Caenorhabditis elegans as a model system for mtDNA replication defects. [J] . Bratic I, Hench J, Trifunovic A Methods: A Companion to Methods in Enzymology . 2010,第4期

机译：秀丽隐杆线虫（Caenorhabditis elegans）作为mtDNA复制缺陷的模型系统。
4. A neural network model of Caenorhabditis elegans and simulation of chemotaxis-related information processing in the neural network [C] . Sakamoto Kazuma, Soh Zu, Suzuki Michiyo, SAI Intelligent Systems Conference . 2015

机译：秀丽隐杆线虫的神经网络模型和趋化性相关信息处理的模拟
5. Investigations of repressive mechanisms that establish and maintain germline identity throughout Caenorhabditis elegans embryogenesis [D] . Checchi, Paula Marie 2007

机译：在整个秀丽隐杆线虫胚胎发生过程中建立和维持种系同一性的抑制机制的研究
6. Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation [O] . Jessica L. Sullivan-Brown, Panna Tandon, Kim E. Bird, 2016

机译：鉴定椎骨神经管闭合和秀丽隐杆线虫排泄常见的形态发生调节因子。
7. Establishing Caenorhabditis elegans as a model for Mycobacterium avium subspecies hominissuis infection and intestinal colonization [O] . Jamie L. Everman, Navid R. Ziaie, Jessica Bechler, 2015

机译：建立秀丽隐杆线虫（Caenorhabditis elegans）作为鸟分枝杆菌亚种人类感染和肠道定植的模型

Establishing Caenorhabditis elegans as a model for neural tube defects.

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