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Dopaminergic Stimulation in the Brains of Vascular Depression Patients: Neurocognitive and Quantitative EEG (qEEG) Effects.

机译:血管性抑郁症患者大脑中的多巴胺能刺激:神经认知和定量EEG(qEEG)效应。

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摘要

This study of archival-data acquired has investigated the effect of methylphenidate on vascular-depression patients via mood-state, cognition, and brain-activity as measured by qEEG. Disruption of dopaminergic tracts of subcortical-cortical pathways may be etiologically relevant to vascular-depression and hence amenable to treatment with methylphenidate (Mayberg, 2003). Results of our data indicate that significant improvements in neurocognitive domains and mood were present postmethylphenidate. Regarding neurophysiology, paired t-tests comparing qEEG patterns pre and post methylphenidate indicate frontal-decreases in beta and frontal/temporal slow-wave increases noted bilaterally following drug-administration. Additionally, individual patient's qEEG was compared to a normative-database. A trend toward normalization in frontal-lobe activity was apparent. Based on the results of this study, methylphenidate does seem to have advantageous effects in patients diagnosed with vascular-depression.
机译:这项获得的档案数据研究通过qEEG测量了情绪状态,认知和脑部活动对哌醋甲酯对血管抑郁症患者的影响。皮层下皮质途径的多巴胺能束的破坏可能在病因上与血管抑制有关,因此可以用哌醋甲酯进行治疗(Mayberg,2003)。我们的数据结果表明,哌醋甲酯后存在神经认知域和情绪的显着改善。关于神经生理学,成对的t检验比较了哌醋甲酯之前和之后的qEEG模式,这表明药物给药后双侧β的额叶减少和额叶/颞慢波增加。另外,将个体患者的qEEG与规范数据库进行了比较。额叶活动正常化的趋势很明显。根据这项研究的结果,哌醋甲酯似乎对诊断为血管抑郁的患者具有有利的作用。

著录项

  • 作者

    Kramer, Michelle K.;

  • 作者单位

    The Chicago School of Professional Psychology.;

  • 授予单位 The Chicago School of Professional Psychology.;
  • 学科 Clinical psychology.;Psychobiology.
  • 学位 Psy.D.
  • 年度 2010
  • 页码 123 p.
  • 总页数 123
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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