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首页> 外文学位 >Impact of maternal docosahexaenoic acid (DHA) supplementation in the form of a functional food during pregnancy on infant neurodevelopment: A comparison of vision, memory, temperament and problem-solving abilities.
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Impact of maternal docosahexaenoic acid (DHA) supplementation in the form of a functional food during pregnancy on infant neurodevelopment: A comparison of vision, memory, temperament and problem-solving abilities.

机译：孕期补充功能性食物形式的母体二十二碳六烯酸（DHA）对婴儿神经发育的影响：视力，记忆力，气质和解决问题能力的比较。

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The broad objective of this investigation was to assess the impact of a functional food containing docosahexaenoic acid (22:6n-3, DHA, 300mg/bar, 92 kcal) consumed during pregnancy on infant neurodevelopment. The design was a randomized, longitudinal, double blinded, placebo controlled trial. Intervention was initiated at 24 weeks of pregnancy.;In study 1, infant visual acuity was measured at 4 and 6 months of age using the Acuity Card Procedure (ACP). 30 women consumed the intervention (n=16) or the placebo (n=14). Visual acuity at 4 months of age was better in the DHA group (P=0.018, 3.8+/-1.1 cycles/degree vs. 3.2+/-0.7 cycles/degree). At 6 months there were no differences between groups (P=0.055, 6.0+/-1.3 cycles/degree, 2.6+/-0.3 vs. 5.7+/-1.8 cycles/degree).;In study 2, the Fagan Test of Infant Intelligence (FTII) was administered to infants at 6 and 9 months of age. 36 women consumed the intervention (n=18) or a placebo (n=18). There were no significant differences at 6 or 9 months between groups for any of the FTII outcome variables or over time for the two assessments.;In study 3, we investigated infant problem solving abilities. 29 women consumed the intervention (n=14) or a placebo (n=15). The Infant Planning Test was utilized to assess infants. A significant treatment effect was found for total intention score (P=0.017, 8.01+/-2.35 vs. 6.67+/-3.0), total intentional solutions (P=0.011, 2.5=1.29 vs. 1.67+/-1.5) and number of intentional solutions on both cloth (P=0.008, 3.43+/-1.28 vs. 2.27+/-1.67) and cover (P=0.004, 2.5+/-1.29 vs. 1.73+/-1.62) steps.;In study 4, we investigated infant temperament. 38 women consumed the intervention (n=20) or a placebo (n=18). Infant temperament was assessed using the Infant Characteristics Questionnaire (ICQ) at 6 months and the Revised Infant Temperament Questionnaire (RITQ) at 12 months of age. There were no differences between the DHA and placebo groups for ICQ or RITQ.;A developmental advantage exists in infants related to DHA consumption during pregnancy vis-a-vis a functional food. Our results provide evidence that this advantage begins in early infancy and continues throughout the first 9 months.
机译：这项研究的主要目的是评估怀孕期间食用的含有二十二碳六烯酸（22：6n-3，DHA，300mg / bar，92 kcal）的功能性食品对婴儿神经发育的影响。设计是一项随机，纵向，双盲，安慰剂对照试验。在怀孕24周时开始干预。在研究1中，使用Acuity Card Procedure（ACP）测量了4个月和6个月大的婴儿视敏度。 30名妇女服用了干预措施（n = 16）或安慰剂（n = 14）。 DHA组在4个月大时的视敏度更好（P = 0.018，3.8 +/- 1.1个周期/度对3.2 +/- 0.7个周期/度）。在6个月时，两组之间无差异（P = 0.055，6.0 +/- 1.3个周期/度，2.6 +/- 0.3对5.7 +/- 1.8个周期/度）。在研究2中，婴儿的Fagan测试智力（FTII）用于6个月和9个月大的婴儿。有36名妇女服用了干预措施（n = 18）或安慰剂（n = 18）。对于任何FTII结果变量，或在两次评估中，随着时间的推移，两组之间在6个月或9个月时都没有显着差异。在研究3中，我们调查了婴儿解决问题的能力。有29名妇女服用了干预措施（n = 14）或安慰剂（n = 15）。婴儿计划测试被用来评估婴儿。发现总意向得分（P = 0.017，8.01 +/- 2.35 vs. 6.67 +/- 3.0），总意向解决方案（P = 0.011，2.5 = 1.29 vs. 1.67 +/- 1.5）和数量的治疗效果显着布上的有意溶液（P = 0.008，3.43 +/- 1.28 vs. 2.27 +/- 1.67）和覆盖层（P = 0.004，2.5 +/- 1.29 vs.1.73 +/- 1.62）的步骤;研究4 ，我们调查了婴儿的气质。 38名妇女服用了干预措施（n = 20）或安慰剂（n = 18）。使用6个月大的婴儿特征问卷（ICQ）和12个月大的修订版婴儿气质问卷（RITQ）评估婴儿气质。 DHA组和安慰剂组在ICQ或RITQ方面没有差异。在婴儿中，与功能性食品相比，妊娠期间食用DHA具有发展优势。我们的结果提供了证据，表明这种优势始于婴儿早期，并持续到头9个月。

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