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首页> 外文学位 >Dissociation of vascular dementia and Alzheimer's disease using a sequential working memory and recognition task.
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Dissociation of vascular dementia and Alzheimer's disease using a sequential working memory and recognition task.

机译：使用顺序的工作记忆和识别任务来解离血管性痴呆和阿尔茨海默氏病。

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Previous research suggests that it is possible to differentiate between patients with dementia due to subcortical ischemic white matter disease (i.e. vascular dementia---VaD) from those with Alzheimer's disease (AD), as the former generally demonstrate executive dysfunction within the context of preserved recognition memory (i.e. encoding ability) whereas the opposite pattern is present in patients with AD. Executive abilities, specifically working memory, are important in utilizing the temporal aspects of memory (e.g. the sequence in which events occurred). Thus, a novel test was developed wherein participants were asked to sequence and then recognize a series of letters from among distracters with the expectation that the VaD patients would perform more poorly on the sequencing task whereas those with AD would do worse on the recognition component. Participants with mild AD (n=14), mild VaD (n=13), and healthy controls (n=10) were administered the experimental task and traditional neuropsychological tests of working memory and recognition memory. The patients were diagnosed with either AD or VaD and were required to have either low or high white matter damage, respectively, as evidenced by MRI scans. The VaD group performed worse during the sequencing task and also demonstrated difficulty utilizing the temporal aspects of memory. There was some evidence that encoding was relatively preserved in the VaD group compared to the AD patients following even the short delays used in this study (i.e. 15 seconds). Thus, the results support the relationship between executive abilities and the temporal aspects of memory and suggest that white matter damage can result in deficits analogous to those observed with cortical lesions. Additionally, the methods used in the experimental task may hold promise for examining such abilities within these and other populations.
机译：先前的研究表明，可以区分由于皮层下缺血性白质病（即血管性痴呆-VaD）而导致的痴呆症患者与患有阿尔茨海默氏病（AD）的患者，因为前者通常在保留的情况下表现出执行功能障碍识别记忆（即编码能力），而AD患者则呈现相反的模式。执行能力，特别是工作记忆，对于利用记忆的时间方面（例如事件发生的顺序）很重要。因此，开发了一种新颖的测试，其中要求参与者进行排序，然后从分心器中识别出一系列字母，以期VaD患者在测序任务上的表现会更差，而患有AD的患者在识别组件上的表现会更差。对患有轻度AD（n = 14），轻度VaD（n = 13）和健康对照（n = 10）的参与者进行实验任务以及工作记忆和识别记忆的传统神经心理学测试。 MRI扫描证明，这些患者被诊断患有AD或VaD，并分别需要低或高白质损伤。 VaD组在测序任务中表现较差，并且在利用记忆的时间方面也表现出困难。有证据表明，即使在本研究中使用了短暂的延迟（即15秒），与AD患者相比，VaD组中的编码仍相对保留。因此，结果支持了执行能力和记忆的时间方面之间的关系，并表明白质损伤可导致类似于皮质病变所观察到的缺陷。此外，实验任务中使用的方法可能有望在这些人群和其他人群中检查这种能力。

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