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首页> 外文学位 >Adaptation and maladaptation of heart and skeletal muscle to different diets in a rodent model of human obesity.
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Adaptation and maladaptation of heart and skeletal muscle to different diets in a rodent model of human obesity.

机译：在人类肥胖的啮齿动物模型中，心脏和骨骼肌对不同饮食的适应和适应不良。

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摘要

Obesity and diabetes are metabolic disorders associated with fatty acid availability in excess of the tissues' capacity for fatty acid oxidation. This mismatch is implicated in the pathogenesis of cardiac contractile dysfunction and also in skeletal muscle insulin resistance. My dissertation will present work to test the overall hypothesis that "western" and high fat diets differentially affect cardiac and skeletal muscle fatty acid oxidation, the expression of fatty acid responsive genes, and cardiac contractile function. Wistar rats were fed a low fat, "western," or high fat (10%, 45%, or 60% calories from fat, respectively) diet for acute (1 day to 1 week), short (4 to 8 weeks), intermediate (16 to 24 weeks), or long (32 to 48 weeks) term. With high fat diet, cardiac oleate oxidation increased at all time points investigated. In contrast, with western diet cardiac oleate oxidation increased in the acute, short and intermediate term, but not in the long term. Consistent with a maladaptation of fatty acid oxidation, cardiac power (measured ex vivo) decreased with long term western diet only. In contrast to the heart, soleus muscle oleate oxidation increased only in the acute and short term with either western or high fat feeding. Transcript analysis revealed that several fatty acid responsive genes, including pyruvate dehydrogenase kinase 4, uncoupling protein 3, mitochondrial thioesterase 1, and cytosolic thioesterase 1 increased in heart and soleus muscle to a greater extent with high fat diet, versus western diet, feeding. In conclusion, the data implicate inadequate induction of a cassette of fatty acid responsive genes in both the heart and skeletal muscle by western diet resulting in impaired activation of fatty acid oxidation, and the development of cardiac dysfunction.
机译：肥胖和糖尿病是与脂肪酸可利用性相关的代谢性疾病，其超过组织的脂肪酸氧化能力。这种失配与心脏收缩功能障碍的发病机理以及骨骼肌胰岛素抵抗有关。我的论文将介绍检验“西方”饮食和高脂饮食对心脏和骨骼肌脂肪酸氧化，脂肪酸反应基因表达以及心脏收缩功能有不同影响的总体假设的工作。向Wistar大鼠喂低脂，“西脂”或高脂（分别来自脂肪的10％，45％或60％的卡路里），用于急性（1天至1周），短期（4至8周），中期（16至24周）或长期（32至48周）。使用高脂饮食，在所有调查的时间点上，心脏油酸盐的氧化都会增加。相反，在西方饮食中，急性，短期和中期的心脏油酸盐氧化增加，但长期没有增加。与脂肪酸氧化的适应不良相一致，仅长期西餐饮食会降低心脏力量（离体测量）。与心脏相反，比目鱼肌油酸盐氧化仅在西方和高脂喂养的急性和短期内增加。转录本分析显示，与高脂饮食相比，饲喂高脂饮食的心脏和比目鱼肌中有几个脂肪酸响应基因，包括丙酮酸脱氢酶激酶4，解偶联蛋白3，线粒体硫酯酶1和胞质硫酯酶1的增加程度更大。总之，该数据表明西方饮食在心脏和骨骼肌中均未充分诱导出脂肪酸响应基因的表达盒，从而导致脂肪酸氧化的激活受损和心脏功能障碍的发展。

著录项

  • 作者

    Wilson, Christopher Robert.;

  • 作者单位

    The University of Texas Graduate School of Biomedical Sciences at Houston.;

  • 授予单位 The University of Texas Graduate School of Biomedical Sciences at Houston.;
  • 学科 Biology Physiology.
  • 学位 Ph.D.
  • 年度 2007
  • 页码 203 p.
  • 总页数 203
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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