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Alpha electroencephalograph abnormalities in Vietnam-era combat veterans diagnosed with posttraumatic stress disorder.

机译:在越南时代被诊断患有创伤后应激障碍的退伍军人中,阿尔法脑电图异常。

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摘要

The use of EEG and qEEG in the study of PTSD has been unexplored despite data suggesting that negative mood states such as anxiety and depression are associated with specific qEEG findings. All subjects in this study had Novelty Seeking data as measured by Cloninger TCI and eyes-closed EEG. It is hypothesized that, consistent with Davidson's (1993) model, there will be evidence of greater relative right-hemisphere cortical activity among those reporting higher degrees of Novelty Seeking.;Findings among the Low Novelty Seekers include increases in resting alpha activity in the right frontal regions, across the medial temporal, and into left occipital regions. Increases in frontal alpha activity are indicative of decreases in cortical activity. The data demonstrate a left > right hemispheric pattern of increased cortical activity between High compared to Low Novelty Seekers seen in an increase in alpha in the right hemisphere of the Low Novelty Seekers. This is indicative of decreased cortical activity because of the inverse relationship between the alpha rhythm and cortical activity. Greatest statistical significance was found at 9 Hz. Overall activity between 7-16 Hz was localized in Brodmann areas 40, 6, 31 and 32.;Clear differences were found between the High and Low Novelty Seekers based on objective electrophysiological measures. The temperaments of Low Novelty Seekers share the electrophysiological pattern of those who are depressed or anxious, (i.e., avoidant). These findings point to the existence of different neurobiological substrates/cortical networks which are responsible for Novelty Seeking and Novelty Avoiding subsets of PTSD.;Two groups of ten subjects with diagnoses of PTSD were selected on the basis of their degree of reported Novelty Seeking as measured by the TCI. These subjects ranked in the upper or lower third of raw scores on the Novelty Seeking Scale and had EEG data. Using Neuroguide software, High and Low Novelty Seekers were compared with independent sample group t-tests. These data were exported to LORETA to allow the localization of current density in three-dimensional space.
机译:尽管有数据表明,诸如焦虑和抑郁之类的负面情绪状态与特定的qEEG发现有关,但尚未对在PTSD研究中使用EEG和qEEG进行研究。本研究中的所有受试者均具有通过Cloninger TCI和闭眼式EEG测量的“寻求新奇”数据。假设与Davidson(1993)的模型一致,有证据表明在那些寻求更高程度的新奇寻求者中右半球相对皮层活动增强;低新奇寻求者中的发现包括右侧静息α活性的增加。额叶区域,横跨颞内侧,并进入左枕骨区域。额叶α活性的增加表明皮质活性的降低。数据表明,与低新奇寻求者相比,高与低新奇寻找者之间的皮层活动从左到右的半球模式表现为低新奇寻找者的右半球的alpha值增加。由于阿尔法节律与皮质活动之间呈反比关系,这表明皮质活动减少。在9 Hz处发现最大的统计显着性。整体活动在7-16 Hz之间位于Brodmann地区40、6、31和32 .;根据客观的电生理指标,发现高新奇寻求者和低新奇寻求者之间存在明显差异。低新奇寻求者的性情与沮丧或焦虑(即回避者)的人的电生理模式相同。这些发现表明存在着不同的神经生物学底物/皮层网络,它们负责PTSD的新颖性寻找和避免新颖性子集。;根据测得的新颖性寻求程度,选择了十名诊断为PTSD的受试者的两组由TCI。这些对象在“新奇寻求”量表的原始评分中排名较高或较低,并且具有EEG数据。使用Neuroguide软件,将高和低新奇搜寻者与独立样本组t检验进行比较。这些数据被导出到LORETA,以允许在三维空间中定位电流密度。

著录项

  • 作者

    Brietzke, Colin A.;

  • 作者单位

    The Chicago School of Professional Psychology.;

  • 授予单位 The Chicago School of Professional Psychology.;
  • 学科 Biology Neuroscience.;Biophysics Medical.;Psychology Physiological.;Psychology Clinical.
  • 学位 Psy.D.
  • 年度 2010
  • 页码 117 p.
  • 总页数 117
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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