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首页> 外文学位 >A Health Technology Assessment of a Proposed Biosimilar for the Treatment of Chemotherapy Induced Febrile Neutropenia: A U.S. Payer Perspective.
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A Health Technology Assessment of a Proposed Biosimilar for the Treatment of Chemotherapy Induced Febrile Neutropenia: A U.S. Payer Perspective.

机译：拟议的生物仿制药用于化学疗法诱导的发热性中性粒细胞减少症的健康技术评估：美国付款人观点。

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摘要

he goal of this comparative technology assessment was to estimate the economic value as well as clinical value of a proposed biosimilar from a US payer perspective. The biosimilar is compared to filgrastim and pegfilgrastim, intended for the treatment of chemotherapy induced febrile neutropenia (CIN). A decision analytical model was designed and implemented using TreeAge Pro 2013 software. The initial cost and clinical estimates were based on similar model published by Eldar-Lissai (2008). The model was modified to include a proposed biosimilar expected to be released in the U.S. in 2014. Modified and updated clinical and cost estimates were input into the model and costs were adjusted for 2013 using the CPI for medical care. Costs and outcomes were estimated for a time horizon of one chemotherapy cycle. Sensitivity analyses, including Monte Carlo probabilistic analyses, were conducted to assess the robustness of the model. The model estimated expected costs for the three therapies to be:
机译：这项比较技术评估的目的是从美国付款人的角度评估拟议生物仿制药的经济价值和临床价值。将生物仿制药与非格司亭和培格非司亭进行比较，后者旨在用于治疗化疗引起的发热性中性粒细胞减少症（CIN）。使用TreeAge Pro 2013软件设计并实施了决策分析模型。初始费用和临床估算基于Eldar-Lissai（2008）发布的类似模型。对模型进行了修改，以包括拟于2014年在美国发布的拟议生物仿制药。对模型进行了修改和更新的临床和成本估算，并使用医疗保健CPI在2013年调整了成本。在一个化疗周期的时间范围内估计成本和结果。进行敏感性分析，包括蒙特卡洛概率分析，以评估模型的鲁棒性。该模型估计这三种疗法的预期费用为：

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  • 作者

    Vaidya, Neel.;

  • 作者单位

    Albany College of Pharmacy and Health Sciences.;

  • 授予单位 Albany College of Pharmacy and Health Sciences.;
  • 学科 Health Sciences Pharmacology.;Health Sciences Oncology.;Health Sciences Pharmacy.
  • 学位 M.S.
  • 年度 2013
  • 页码 112 p.
  • 总页数 112
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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