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An assessment of novel biodegradable magnesium alloys for endovascular biomaterial applications.

机译：对用于血管内生物材料应用的新型可生物降解镁合金的评估。

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摘要

Magnesium alloys have been widely explored as potential biomaterials, but several limitations to using these materials have prevented their widespread use, such as uncontrollable degradation kinetics which alter their mechanical properties. In an attempt to further the applicability of magnesium and its alloys for biomedical purposes, two novel magnesium alloys Mg-Zn-Cu and Mg-Zn-Se were developed with the expectation of improving upon the unfavorable qualities shown by similar magnesium based materials that have previously been explored. The overall performance of these novel magnesium alloys has been assessesed in three distinct phases of research: 1) analysing the mechanical properties of the as-cast magnesium alloys, 2) evaluating the biocompatibility of the as-cast magnesium alloys through the use of in-vitro cellular studies, and 3) profiling the degradation kinetics of the as-cast magnesium alloys through the use of electrochemical potentiodynamic polarization techqnique as well as gravimetric weight-loss methods. As compared to currently available shape memory alloys and degradable as-cast alloys, these experimental alloys possess superior as-cast mechanical properties with elongation at failure values of 12% and 13% for the Mg-Zn-Se and Mg-Zn-Se alloys, respectively. This is substantially higher than other as-cast magnesium alloys that have elongation at failure values that range from 7-10%. Biocompatibility tests revealed that both the Mg-Zn-Se and Mg-Zn-Cu alloys exhibit low cytotoxicity levels which are suitable for biomaterial applications. Gravimetric and electrochemical testing was indicative of the weight loss and initial corrosion behavior of the alloys once immersed within a simulated body fluid. The development of these novel as-cast magnesium alloys provide an advancement to the field of degradable metallic materials, while experimental results indicate their potential as cost-effective medical devices.
机译：镁合金已被广泛地探索为潜在的生物材料，但是使用这些材料的一些局限性阻止了它们的广泛使用，例如不可控制的降解动力学改变了其机械性能。为了进一步提高镁及其合金在生物医学中的应用性，人们开发了两种新型镁合金Mg-Zn-Cu和Mg-Zn-Se，期望改善类似镁基材料所具有的不利质量。以前已经探索过。已在三个不同的研究阶段对这些新型镁合金的整体性能进行了评估：1）分析铸态镁合金的机械性能，2）通过使用以下方法评估铸态镁合金的生物相容性：体外细胞研究，以及3）通过使用电化学势动力极化技术以及重量失重法，对铸态镁合金的降解动力学进行分析。与目前可用的形状记忆合金和可降解铸态合金相比，这些实验合金具有优异的铸态机械性能，Mg-Zn-Se和Mg-Zn-Se合金的破坏值伸长率分别为12％和13％ ， 分别。这大大高于在7-10％的破坏值下具有伸长率的其他铸态镁合金。生物相容性测试表明，Mg-Zn-Se和Mg-Zn-Cu合金均显示出低的细胞毒性水平，适用于生物材料的应用。重量和电化学测试表明，一旦浸入模拟体液中，合金的重量损失和初始腐蚀行为。这些新颖的铸态镁合金的发展为可降解金属材料领域提供了发展，而实验结果表明它们具有成本效益的医疗器械潜力。

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  • 作者

    Persaud-Sharma, Dharam.;

  • 作者单位

    Florida International University.;

  • 授予单位 Florida International University.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 151 p.
  • 总页数 151
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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