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首页> 外文学位 >From nutritional status to mental health: Evidence of a relation of iron status to cognitive performance and depressive symptoms in older adults from the InCHIANTI study.
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From nutritional status to mental health: Evidence of a relation of iron status to cognitive performance and depressive symptoms in older adults from the InCHIANTI study.

机译：从营养状况到心理健康：InCHIANTI研究表明，铁的状况与老年人的认知能力和抑郁症状有关。

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摘要

Nutritional deficiencies and mental and behavioral disorders rank among the leading causes of global disability. The goal of this dissertation research was to investigate the relation of iron status, as measured by an array of complete blood count and iron-specific measures, to both cognitive performance and depressive symptoms in older adults in the InCHIANTI study. We first carefully developed multiple methods based on the scientific literature to characterize iron status in order to assess if nontraditional methods that took age and inflammation into consideration would be more accurate in characterizing iron status than methods that used traditional cutoffs typically applied to younger populations. We then used our results from this assessment to look at the relation between iron status, as determined by the optimal method of iron status characterization that considers both age and inflammation, and cognitive performance and depressive symptoms in the InCHIANTI elderly as measured by the Mini-Mental State Examination (MMSE); the Trail Making Test (TMT); and the Center for Epidemiologic Studies Depression Scale (CES-D). We hypothesized that individuals with poorer iron status would perform worse on cognitive tests, and we hypothesized that individuals with poorer iron status would have more depressive symptoms compared to those with relatively better iron status.;In statistical analyses using data at baseline and then in separate analyses using longitudinal data from four time points, we found significant associations relating poorer iron status to poorer cognitive performance, controlling for a variety of demographic, nutritional, and medically related covariates. We also found significant associations between iron status and depressive symptoms, although some of these relations were in an unexpected direction.;In conclusion, using a novel combination of methods from scientifically based literature to optimally characterize iron status in elderly InCHIANTI individuals, we found evidence both cross-sectionally at baseline and longitudinally using data across multiple time points in favor of a relation between poor iron status and poor mental health outcomes. Acknowledging a possible relation between iron status and mental health may more efficiently advance research and practice to effectively seek solutions to improve the status of both.
机译：营养缺乏以及精神和行为障碍是导致全球残疾的主要原因。本论文研究的目的是调查通过全血细胞计数和铁特异性措施测量的铁状态与老年人的认知表现和抑郁症状之间的关系。我们首先根据科学文献精心开发了多种方法来表征铁的状态，以便评估将年龄和炎症因素考虑在内的非传统方法在表征铁的状态方面是否比使用通常用于年轻人群的传统临界值的方法更准确。然后，我们使用这项评估的结果来研究铁状态（通过考虑年龄和炎症的铁状态表征的最佳方法确定的铁状态）与Inchianti老年人的认知能力和抑郁症状之间的关系（如Mini-精神状态考试（MMSE）；追踪测试（TMT）；以及流行病学研究中心抑郁量表（CES-D）。我们假设铁质状况较差的人在认知测试中表现较差，并且我们假设铁质状况较差的人与铁质状况相对较好的人相比，抑郁症状会更严重。使用来自四个时间点的纵向数据进行分析，我们发现了铁水平较差与认知能力较差之间的显着关联，并控制了各种人口统计学，营养学和医学相关的协变量。我们还发现了铁状态与抑郁症状之间的显着关联，尽管其中一些关系是出乎意料的。;总之，使用科学文献中的新颖方法组合来最佳地表征了老年人INCHIANTI个人的铁状态，我们发现了证据在基线时横断面和纵向使用多个时间点的数据，以支持不良铁状态与不良心理健康结果之间的关系。认识到铁状态与心理健康之间可能存在的联系可能会更有效地推进研究和实践，以有效地寻求改善两者状况的解决方案。

著录项

  • 作者

    Chen, Lenis Pangwun.;

  • 作者单位

    The Johns Hopkins University.;

  • 授予单位 The Johns Hopkins University.;
  • 学科 Health Sciences Mental Health.;Psychology Cognitive.;Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 210 p.
  • 总页数 210
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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