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首页> 外文学位 >Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120.
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Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120.

机译：使用Advia 120/2120在骑士查尔斯国王猎犬和灵狮中的血小板计数和血小板临界值。

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摘要

Background: Models for the regulation of thrombopoiesis predict that platelet mass is the biologically regulated parameter, yet clinical evaluations are often based on platelet number. When there is concurrent thrombocytopenia and variation in platelet size, platelet count may poorly estimate total platelet mass, confounding clinical decision making.;Objective: We hypothesize that plateletcrit provides clinically important information when platelet number is an incomplete representation of platelet mass, such as in genetic macrothrombocytopenia.;Methods: We retrospectively compared platelet count and plateletcrits with general reference intervals for four groups of dogs: sick Cavalier King Charles Spaniels and Greyhounds that presented for non-hematopoietic disease to the University of Minnesota (Advia 2120) and Auburn University Teaching Hospitals (Advia 120) over a 3 year period.;Results: A canine plateletcrit reference interval of 0.129--0.403 % was established. None of the four sample groups were found to have significantly more individuals below the reference interval for plateletcit. For platelet count, only the Cavalier groups were found to have significantly more individuals below the reference interval than predicted.;Conclusion: Use of the plateletcrit as determined by the Advia 120/2120 appeared to avoid overestimation of low platelet mass in sick Cavalier Kind Charles Spaniels in a clinical setting. In contrast, the plateletcrit performed similarly to the platelet count in evaluation of platelet mass in sick Greyhounds. Evaluation of the plateletcrit should be considered in other conditions associated with increased mean platelet volume.
机译：背景：血小板生成调节模型预测血小板质量是生物学调节的参数，但临床评估通常基于血小板数量。当同时存在血小板减少症和血小板大小变化时，血小板计数可能无法很好地估计总血小板量，从而混淆了临床决策。目的：我们假设，当血小板数不能完全代表血小板量时，例如，血小板减少症可提供临床上重要的信息。方法：我们回顾性比较了四组狗的血小板计数和血小板计数与一般参考间隔：向明尼苏达大学（Advia 2120）和非明尼苏达大学呈报的针对非造血性疾病的患病骑士查尔斯·金毛猎犬和灵狮医院（Advia 120）历时3年;结果：建立了犬血小板血小板参考间隔为0.129--0.403％。发现四个样本组中没有一个在血小板参考区间以下有明显更多的个体。对于血小板计数，仅在参考间隔以下才发现骑士组的个体比预期的多得多。结论：使用Advia 120/2120确定的血小板临界值似乎可以避免高估患病的骑士查尔斯的低血小板量在临床环境中的西班牙猎狗。相反，在患病的灵缇犬中评估血小板质量与评估血小板计数的效果相似。在与平均血小板体积增加相关的其他情况下，应考虑评估血小板暴积。

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  • 作者

    Kelley, Jessica Anne.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Agriculture Animal Pathology.;Biology Veterinary Science.
  • 学位 M.S.
  • 年度 2013
  • 页码 78 p.
  • 总页数 78
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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