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首页> 外文学位 >Characterization of Host Immune Responses to Eimeria adenoeides Infection in Turkey Poults.
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Characterization of Host Immune Responses to Eimeria adenoeides Infection in Turkey Poults.

机译：表征对土耳其家禽对艾美尔球虫感染的宿主免疫反应。

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摘要

Coccidiosis is a common enteric disease of turkeys that is caused by protozoan parasites belonging to the genus Eimeria. There are about seven species of Eimeria that affect turkeys and of these E. adenoeides is the most pathogenic and commonly recognized. Infection with Eimeria is known to induce a long lasting protective immunity in chickens, but nothing is known regarding the acquisition of immunity to Eimeria in turkeys. The experiments reported here were aimed at investigating the biological and cellular immune response to E. adenoeides in turkey poults under different conditions of exposure. In experiment 1 (Chapter II), 20 day old poults were infected with 12.5 × 103 oocysts and shown to develop immunity when challenged with a high dose of oocysts at 34 days of age, as judged by weight gain and oocyst production. Changes in peripheral blood leukocytes following the primary exposure were investigated, and an increase in the number of total lymphocytes, monocytes, and subsets of lymphocytes (CD4+ and CD8+) was shown in infected poults compared to uninfected controls.;In experiment 2 (Chapter III), local immune activities occurring in the ceca in response to infection were investigated. An increase in leukocyte infiltration, percent area occupied by CD4+ and CD8+ lymphocytes, and relative expression of cytokines (CXCLi2, IL1β, IFNγ, IL10, and IL13) was observed in the ceca following infection. In experiment 3 (Chapter IV), we attempted to model the field situation by investigating the acquisition of immunity under conditions poults could encounter following placement upon built-up litter. Results indicated that they had acquired partial protection judged by weight gain and mortality by day 12 and 18 following challenge. The leukocyte infiltration score, percent area occupied by CD4+ and CD8+ lymphocytes, and expression of the cytokines (CXCLi2, IL1β, IFNγ, IL2, IL10, IL12b, IL13, and IL18) in the ceca significantly increased following infection. The changes in the ceca of E. adenoeides infected poults, in terms of infiltration of leukocytes, the area occupied by various subsets of lymphocytes, and the relative expression of chemokines and cytokines characterize the development of innate and adaptive immune activities.
机译：球虫病是火鸡的一种常见的肠道疾病，它是由属于艾美球虫属的原生动物寄生虫引起的。影响火鸡的艾美耳球虫大约有七种，其中腺苷是最致病的，也是公认的。已知在鸡中感染艾美尔球虫会诱导持久的保护性免疫，但对于在火鸡中获得对艾美尔球虫的免疫力却一无所知。本文报道的实验旨在研究在不同暴露条件下火鸡对腺苷的生物和细胞免疫反应。在实验1（第二章）中，根据体重增加和卵囊产生的判断，在20天大的家禽中感染了12.5×103卵囊，并在34天龄受到高剂量卵囊攻击时显示出免疫力。研究了初次暴露后外周血白细胞的变化，与未感染的对照组相比，感染的家禽的总淋巴细胞，单核细胞和淋巴细胞亚群（CD4 +和CD8 +）的数量有所增加。实验2（第三章） ），调查了响应感染在盲肠中发生的局部免疫活性。感染后盲肠中白细胞浸润，CD4 +和CD8 +淋巴细胞占据的面积百分比增加以及细胞因子（CXCLi2，IL1β，IFNγ，IL10和IL13）的相对表达增加。在实验3（第四章）中，我们试图通过调查在堆积的垫料放置后家禽可能遇到的条件下获得免疫力来对田间情况进行建模。结果表明，在攻击后第12天和第18天，根据体重增加和死亡率判断，他们已经获得了部分保护。感染后，盲肠中白细胞浸润评分，CD4 +和CD8 +淋巴细胞占据的面积百分比以及细胞因子（CXCLi2，IL1β，IFNγ，IL2，IL10，IL12b，IL13和IL18）的表达明显增加。从白细胞的浸润，淋巴细胞的各种亚群所占的面积以及趋化因子和细胞因子的相对表达等方面来说，腺病毒大肠杆菌感染的盲肠的盲肠变化是先天性和适应性免疫活动发展的特征。

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  • 作者

    Gadde, Ujvala Deepthi.;

  • 作者单位

    University of Arkansas.;

  • 授予单位 University of Arkansas.;
  • 学科 Biology Molecular.;Health Sciences Immunology.;Biology Parasitology.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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