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首页> 外文学位 >The effect of post-exercise caffeine and chlorogenic acid supplementation on blood glucose disposal and insulin sensitivity.
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The effect of post-exercise caffeine and chlorogenic acid supplementation on blood glucose disposal and insulin sensitivity.

机译：运动后补充咖啡因和绿原酸对血糖处置和胰岛素敏感性的影响。

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摘要

Caffeine and chlorogenic acid are two compounds in green coffee beans that alter blood glucose disposal and insulin sensitivity. Caffeine has been shown to decrease glucose disposal and insulin sensitivity when taken 60 minutes prior to an oral glucose tolerance test in humans, whereas chlorogenic acid has been shown to increase glucose disposal and insulin sensitivity in humans. The purpose of this study was to investigate the effect of ingesting caffeine with dextrose or chlorogenic acid with dextrose immediately after an exhaustive bout of cycling on blood glucose and insulin disposal when compared to ingesting dextrose alone. Ten men (age: 26 +/- 5 years; height: 179.9 +/- 5.4 cm; weight: 77.6 +/- 13.3 kg; BMI: 24.0 +/- 4.3; VO2 peak: 55.9 +/- 8.4 ml·kg--1·min--1 ) who were moderately to highly trained cyclists participated in this study. Each participant completed three experimental trials in random order the morning after abstaining from food, caffeine, and chlorogenic acid supplements for 12 hours. Each trial consisted of a 30-minute high intensity bout of cycling at 60% of peak power output (~90% HR max). Immediately after the exercise, each participant consumed 5 mg/kg body weight of caffeine plus 75 g of dextrose (CAF), 5 mg/kg body weight of chlorogenic acid plus 75 g of dextrose (CGA), or 5 mg/kg body weight of dextrose plus 75 g dextrose (PLA). Blood was drawn to measure glucose and insulin immediately before exercise, immediately after exercise, every 15 minutes during the first hour of recovery, and every 30 minutes during the second hour of recovery. The blood glucose and insulin area under the curve (AUC) and Matsuda insulin sensitivity index (ISI) were calculated for each trial. There were no significant time-by-treatment effects for blood glucose and insulin. The two-hour glucose and insulin AUCs, respectively, for the CAF (658 +/- 74 mmol/L and 30,005 +/- 13,304 pmol/L), CGA (637 +/- 100 mmol/L and 31,965 +/- 23,586 pmol/L), and PLA (661 +/- 77 mmol/L and 27,020 +/- 12,339 pmol/L) trials were not significantly different (p > .05). The ISI for the CAF (9.7 +/- 5.2), CGA (12.1 +/-7.9), and PLA (10.0 +/- 7.3) trials were also not significantly different (p > .05). There was substantial inter-subject variability in glucose and insulin responses during the three trials that likely contributed to the non-significant findings. Pearson correlation analyses were conducted to investigate variables that contributed to this variability. Body mass index was highly related to insulin AUC for the CAF (r = .71), CGA (r = .80), and PLA (r = .73) trials. Relative VO2 peak was moderately-to-highly related to insulin AUC for the CAF (r = -.82), CGA (r = -.63), and PLA (r = -.63) trials. In conclusion, caffeine and chlorogenic acid may affect the body's ability to regulate post-exercise insulin-mediated glucose transport into the exercised skeletal muscle through different mechanisms; however more research is warranted to verify this hypothesis. Additionally, body composition and training status should be similar to lessen the variability between subjects for investigations of glucose tolerance and insulin sensitivity.
机译：咖啡因和绿原酸是生咖啡豆中的两种化合物，会改变血糖处置和胰岛素敏感性。在人体内口服葡萄糖耐量试验前60分钟服用咖啡因已显示可降低葡萄糖处置和胰岛素敏感性，而绿原酸已显示可在人体中增加葡萄糖处置和胰岛素敏感性。这项研究的目的是研究与单独摄入右旋糖相比，在彻底循环后立即摄入咖啡因和右旋糖或绿原酸和右旋糖对血糖和胰岛素处置的影响。十名男性（年龄：26 +/- 5岁;身高：179.9 +/- 5.4厘米;体重：77.6 +/- 13.3千克;体重指数：24.0 +/- 4.3; VO2峰值：55.9 +/- 8.4毫升·kg- -1·min--1）（中等至训练有素的自行车手）参加了这项研究。每位参与者从食物，咖啡因和绿原酸补充剂中戒除12小时后，于早晨随机完成了三项实验。每个试验都包括以60％峰值功率输出（约90％HR max）的30分钟高强度循环运动。运动后，每位参与者立即消耗5 mg / kg体重的咖啡因加75 g葡萄糖（CAF），5 mg / kg绿原酸加上75 g葡萄糖（CGA）或5 mg / kg体重葡萄糖加75克葡萄糖（PLA）。紧接运动前，运动后，恢复的第一小时内每15分钟和恢复的第二小时内每30分钟抽血以测量葡萄糖和胰岛素。计算每个试验的血糖和曲线下胰岛素面积（AUC）和松田胰岛素敏感性指数（ISI）。血糖和胰岛素没有明显的分时治疗效果。 CAF（658 +/- 74 mmol / L和30,005 +/- 13,304 pmol / L），CGA（637 +/- 100 mmol / L和31,965 +/- 23,586）分别为两个小时的葡萄糖和胰岛素AUC pmol / L）和PLA（661 +/- 77 mmol / L和27,020 +/- 12,339 pmol / L）试验没有显着差异（p> .05）。 CAF（9.7 +/- 5.2），CGA（12.1 +/- 7.9）和PLA（10.0 +/- 7.3）试验的ISI也没有显着差异（p> .05）。在这三项试验中，受试者的血糖和胰岛素反应存在很大的变异性，这很可能导致了不重要的发现。进行了Pearson相关分析，以调查导致这种可变性的变量。在CAF（r = .71），CGA（r = .80）和PLA（r = .73）试验中，体重指数与胰岛素AUC高度相关。在CAF（r = -.82），CGA（r = -.63）和PLA（r = -.63）试验中，相对VO2峰值与胰岛素AUC呈中度至高度相关性。总之，咖啡因和绿原酸可能会通过不同的机制影响人体调节运动后胰岛素介导的葡萄糖向运动骨骼肌的转运的能力。但是，需要进行更多的研究来验证这一假设。此外，身体成分和训练状态应相似，以减少受试者之间对葡萄糖耐量和胰岛素敏感性的研究之间的差异。

著录项

  • 作者

    Beam, Jason R.;

  • 作者单位

    The University of New Mexico.;

  • 授予单位 The University of New Mexico.;
  • 学科 Health Sciences Recreation.;Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 133 p.
  • 总页数 133
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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